ArticleThe Journal of investigative dermatology2016
Characterization of Lipoprotein Composition and Function in Pediatric Psoriasis Reveals a More Atherogenic Profile.
Article in The Journal of investigative dermatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 55 citations in OpenAlex.
- Systematic Literature Reviews on the Disease Burden of Pediatric Psoriasis.Dermatology and therapy · 2025Review
- The Association Between Psoriasis and Metabolic Syndrome in Children: A Narrative Review.Metabolites · 2025Review
- HOMA-IR Index and Pediatric Psoriasis Severity-A Retrospective Observational Study.Life (Basel, Switzerland) · 2024Article
- The relationship between blood lipid and risk of psoriasis: univariable and multivariable Mendelian randomization analysis.Frontiers in immunology · 2023Article
- Elevated cholesteryl ester transfer and phospholipid transfer proteins aggravated psoriasis in imiquimod-induced mouse models.Lipids in health and disease · 2022Article
- Metabolic Comorbidities and Cardiovascular Disease in Pediatric Psoriasis: A Narrative Review.Healthcare (Basel, Switzerland) · 2022Article
- Formation and Cellular Impact of Cholesterol Crystals in Health and Disease.Advanced biology · 2021Review
- Psoriasis and Atherosclerosis-Skin, Joints, and Cardiovascular Story of Two Plaques in Relation to the Treatment with Biologics.International journal of molecular sciences · 2021Review
- Association of Metabolic Comorbidities with Pediatric Psoriasis: A Systematic Review and Meta-Analysis.Annals of dermatology · 2021Article
- Current Understanding of the Immunomodulatory Activities of High-Density Lipoproteins.Biomedicines · 2021Review
- Review
- Liangxue Jiedu Formula Improves Psoriasis and Dyslipidemia ComorbidityFrontiers in pharmacology · 2021Article
- Cutaneous and Systemic Psoriasis: Classifications and Classification for the Distinction.Frontiers in medicine · 2021Review
- High-Density Lipoprotein (HDL) in Allergy and Skin Diseases: Focus on Immunomodulating Functions.Biomedicines · 2020Review
- Article
- Chronic skin inflammation accelerates macrophage cholesterol crystal formation and atherosclerosis.JCI insight · 2018Article
- Psoriasis and Cardiovascular Comorbidities: Focusing on Severe Vascular Events, Cardiovascular Risk Factors and Implications for Treatment.International journal of molecular sciences · 2017Review
- Psoriasis-associated vascular disease: the role of HDL.Journal of biomedical science · 2017Review
- Pediatric Psoriasis Comorbidity Screening Guidelines.JAMA dermatology · 2017Article
- Psoriasis and comorbid diseases: Epidemiology.Journal of the American Academy of Dermatology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Psoriasis is associated with increased cardiovascular disease in adults, but the risk profile of children with psoriasis remains to be fully characterized. We measured lipoprotein composition and function in 44 patients with pediatric psoriasis and 44 age- and sex-matched healthy controls, using nuclear magnetic resonance spectroscopy and a validated ex vivo assay of high-density lipoprotein cholesterol efflux capacity. The mean age of the patients was 13 years and the population was ethnically diverse. Children with psoriasis had higher waist-to-hip ratios (0.85 vs. 0.80; P < 0.002) and insulin resistance measures (log-transformed homeostasis model assessment of insulin resistance 0.65 vs. 0.41; P = 0.07). Despite comparable traditional lipid values, having psoriasis was associated with higher apolipoprotein B concentrations (72.4 vs. 64.6; P = 0.02), decreased large high-density lipoprotein particles (5.3 vs. 6.7; P < 0.01), and reduced cholesterol efflux capacity after adjusting for age, sex, fasting glucose, homeostasis model assessment of insulin resistance, systolic blood pressure, body mass index, apolipoprotein A-1, and high-density lipoprotein cholesterol concentration (β -0.22; P = 0.02). Patients with pediatric psoriasis have a more atherogenic cardiometabolic risk profile, with evidence of insulin resistance and lipoprotein dysfunction by particle size, number, and functional assessment. These findings may provide a basis for the observed link later in life between psoriasis and cardiovascular disease, and support the need to screen and educate young patients to minimize later complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.