ArticleThe Journal of investigative dermatology2016
Mind the Gap: Sex Bias in Basic Skin Research.
Article in The Journal of investigative dermatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Tendinopathy: sex bias starts from the preclinical development of tendon treatments. A systematic review.Biology of sex differences · 2022Pooled it
- AI-assisted Total Body Dermoscopic Evaluation of Changes in Melanocytic Nevi during Pregnancy: A Prospective, Comparative Study of 2,799 Nevi.Acta dermato-venereologica · 2025Article
- The rat as an animal model in chronic wound research: An update.Life sciences · 2024Review
- Gender Differences in Post-Operative Human Skin.Biomedicines · 2023Article
- Male or female sex: considerations and translational aspects in diabetic foot ulcer research using rodent models.Molecular and cellular biochemistry · 2023Review
- Dietary energy intake across the menstrual cycle: a narrative review.Nutrition reviews · 2023Review
- Minimal influence of estrous cycle on studies of female mouse behaviors.Frontiers in molecular neuroscience · 2023Article
- Sex Inequalities in Medical Research: A Systematic Scoping Review of the Literature.Women's health reports (New Rochelle, N.Y.) · 2022Article
- Large-scale labeling and assessment of sex bias in publicly available expression data.BMC bioinformatics · 2021Article
- Various aspects of sex and gender bias in biomedical research.Physiological research · 2020Review
- Article
- Sex-based Differences in Hearing Loss: Perspectives From Non-clinical Research to Clinical Outcomess.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2020Review
- Sexual dimorphism in atrophic effects of topical glucocorticoids is driven by differential regulation of atrophogene REDD1 in male and female skin.Oncotarget · 2020Article
- Opinion: Research community needs to better appreciate the value of sex-based research.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Sex bias in basic and preclinical age-related hearing loss research.Biology of sex differences · 2018Review
- Sex as an important biological variable in biomedical research.BMB reports · 2018Review
- Innate Sex Bias ofJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- Enhancing Scientific Foundations to Ensure Reproducibility: A New Paradigm.The American journal of pathology · 2018Article
- Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis.Genome medicine · 2017Article
- Is sex bias orchestrated in the skin?Nature immunology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Given the recent National Institutes of Health proposal for balanced use of male and female cells and animals in preclinical studies, we explored whether sex bias exists in skin research. We surveyed 802 dermatological research articles from 2012 through 2013. No information about the sex of studied cells or animals was provided in 60% of papers. Among keratinocytes of known sex, 70% were male. Few studies compared male versus female cells or animals. Disclosure of sex and comparative studies contribute to our understanding of the biologic basis of sex differences. Addressing sex-specific differences in preclinical research informs subsequent clinical trial design and promotes individualized therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.