ArticleNorth Carolina medical journal
Enrollment and Racial Disparities in Cancer Treatment Clinical Trials in North Carolina.
Article in North Carolina medical journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Digital Health Platform for Maternal Health: Design, Recruitment Strategies, and Lessons Learned From the PowerMom Observational Cohort Study.JMIR formative research · 2025Observational
- The role of social, economic, and medical marginalization in cancer clinical trial participation inequities: A systematic review.Journal of clinical and translational science · 2025Review
- Racial and ethnic associations with comprehensive cancer center access and clinical trial enrollment for acute leukemia.Journal of the National Cancer Institute · 2024Article
- Equitable inclusion of diverse populations in oncology clinical trials: deterrents and drivers.ESMO open · 2024Review
- Access to cancer clinical trials for racialised older adults: an equity-focused rapid scoping review protocol.BMJ open · 2024Article
- Racial survival disparities in head and neck cancer clinical trials.Journal of the National Cancer Institute · 2023Article
- Associations Between Race/Ethnicity, Language, and Enrollment on Cancer Research Studies.The oncologist · 2023Article
- Disparities in awareness of and willingness to participate in cancer clinical trials between African American and White cancer survivors.BMC cancer · 2022Article
- Barriers for cancer clinical trial enrollment: A qualitative study of the perspectives of healthcare providers.Contemporary clinical trials communications · 2022Article
- Differences in Inflammation, Treatment, and Outcomes Between Black and Non-Black Patients Hospitalized for COVID-19: A Prospective Cohort Study.The American journal of medicine · 2022Article
- Health Insurance Payer Type and Ethnicity Are Associated with Cancer Clinical Trial Enrollment Among Adolescents and Young Adults.Journal of adolescent and young adult oncology · 2022Article
- Health Disparities in Recruitment and Enrollment in Research.Thoracic surgery clinics · 2022Review
- Project PLACE: Enhancing community and academic partnerships to describe and address health disparities.Advances in cancer research · 2020Review
- Multilevel analysis in rural cancer control: A conceptual framework and methodological implications.Preventive medicine · 2019Article
- How current reporting practices may mask differences: A call for examining cancer-specific demographic enrollment patterns in cancer treatment clinical trials.Contemporary clinical trials communications · 2019Article
- Science in the Heartland: Exploring determinants of offering cancer clinical trials in rural-serving community urology practices.Urologic oncology · 2019Article
- Linking Education to Action: A Program to Increase Research Participation Among African American Women.Journal of women's health (2002) · 2018Article
- Making the Case for Investment in Rural Cancer Control: An Analysis of Rural Cancer Incidence, Mortality, and Funding Trends.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Article
- Next steps to improve disparities in lung cancer treatment clinical trial enrollment.Annals of translational medicine · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundClinical trials provide access to innovative, high-quality cancer treatment. Simultaneously, broad access helps to ensure that trials include heterogeneous patient populations, which improves the generalizability of findings and the development of interventions that are effective for diverse populations. We provide updated data describing enrollment into cancer treatment trials in North Carolina.
methodsFor the period 1996-2009, person-level data regarding cancer clinical trial enrollment and cancer incidence were obtained from the North Carolina Central Cancer Registry and the National Cancer Institute (NCI). Enrollment rates were estimated as the ratio of trial enrollment to cancer incidence for race, sex, and year for each county, Area Health Education Center region, and the state overall. Enrollment rates for common cancers are presented.
resultsFrom 1996 to 2009, North Carolina NCI treatment trial enrollment rates were 2.4% and 2.2% for white patients and minority patients, respectively. From 2007 to 2009, rates were 3.8% for white women, 3.5% for minority women, 1.3% for white men, and 1.0% for minority men; there was greater enrollment among more urban populations (2.4%) than among the most rural populations (1.5%). LIMITATIONS: This study is limited to NCI-sponsored treatment trials in North Carolina. Policies governing collection of original data necessitate a delay in data availability.
conclusionsEffort is needed to ensure trial access and enrollment among all North Carolina populations. Specifically, we identified racial and sex disparities, particularly for certain cancers (eg, breast cancer). Programs in North Carolina and across the nation can use the methods we employed to assess their success in broadening clinical trial enrollment to include diverse populations.
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