Evidence map›Paper›PMID 26762467›Full record

ReviewWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology2016

pH-Sensitive stimulus-responsive nanocarriers for targeted delivery of therapeutic agents.

Mahdi Karimi, Masoud Eslami, Parham Sahandi-Zangabad, Fereshteh Mirab, Negar Farajisafiloo, Zahra Shafaei, Deepanjan Ghosh, Mahnaz Bozorgomid, Fariba Dashkhaneh, Michael R Hamblin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed.

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  12. Magnetic nanoparticles for cancer theranostics.Biomedical physics & engineering express · 2026
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43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mahdi KarimiDepartment of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
Masoud EslamiPolymeric Materials Research Group, Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran.
Parham Sahandi-ZangabadDepartment of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
Fereshteh MirabPolymeric Materials Research Group, Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran.
Negar FarajisafilooPolymeric Materials Research Group, Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran.
Zahra ShafaeiDepartment of Cell & Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.
Deepanjan GhoshDepartment of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran university of Medical science, Tehran, Iran.
Mahnaz BozorgomidDepartment of Applied Chemistry, Central Branch of Islamic Azad University of Tehran, Tehran, Iran.
Fariba DashkhanehDepartment of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran university of Medical Science, Tehran, Iran.
Michael R HamblinWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.

Funding

Photodynamic Therapy of Localized InfectionsR01AI050875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2003 to 2017
$4.8M
NIAID NIH HHS R01 AI050875
6 · The paper itself

Abstract

In recent years miscellaneous smart micro/nanosystems that respond to various exogenous/endogenous stimuli including temperature, magnetic/electric field, mechanical force, ultrasound/light irradiation, redox potentials, and biomolecule concentration have been developed for targeted delivery and release of encapsulated therapeutic agents such as drugs, genes, proteins, and metal ions specifically at their required site of action. Owing to physiological differences between malignant and normal cells, or between tumors and normal tissues, pH-sensitive nanosystems represent promising smart delivery vehicles for transport and delivery of anticancer agents. Furthermore, pH-sensitive systems possess applications in delivery of metal ions and biomolecules such as proteins, insulin, etc., as well as co-delivery of cargos, dual pH-sensitive nanocarriers, dual/multi stimuli-responsive nanosystems, and even in the search for new solutions for therapy of diseases such as Alzheimer's. In order to design an optimized system, it is necessary to understand the various pH-responsive micro/nanoparticles and the different mechanisms of pH-sensitive drug release. This should be accompanied by an assessment of the theoretical and practical challenges in the design and use of these carriers. WIREs Nanomed Nanobiotechnol 2016, 8:696-716. doi: 10.1002/wnan.1389 For further resources related to this article, please visit the WIREs website.

Indexed as

Drug CarriersHydrogen-Ion ConcentrationNanoparticlesAnimalsCell LineHumansMiceModels, BiologicalDrug Carriers

Identifiers

PMID26762467
PMCPMC4945487

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.