ArticleJournal of neurology2016
Motor network structure and function are associated with motor performance in Huntington's disease.
Article in Journal of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- White matter microstructural alterations in Huntington's disease: a systematic review of diffusion imaging findings.Brain imaging and behavior · 2026Pooled it
- Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI.NeuroImage. Clinical · 2023Pooled it
- Aberrant brain network connectivity in presymptomatic and manifest Huntington's disease: A systematic review.Human brain mapping · 2020Pooled it
- Corticoefferent pathology distribution in amyotrophic lateral sclerosis: in vivo evidence from a meta-analysis of diffusion tensor imaging data.Scientific reports · 2018Pooled it
- Large scale functional and effective connectivity alterations cross the Huntington's disease integrated staging system.NeuroImage. Clinical · 2026Article
- Along-Tract Diffusion Alterations in the Dentato-Rubro-Thalamic Tract Correlate With Motor and Cognitive Decline in Huntington's Disease.Human brain mapping · 2025Article
- Striato-cortical connectivity patterns predict clinical profiles in Huntington's disease.NeuroImage. Clinical · 2025Article
- Article
- Classification of Huntington's Disease Stage with Features Derived from Structural and Diffusion-Weighted Imaging.Journal of personalized medicine · 2022Article
- Differential tractography as a dynamic imaging biomarker: A methodological pilot study for Huntington's disease.NeuroImage. Clinical · 2022Article
- Diffusion imaging in Huntington's disease: comprehensive review.Journal of neurology, neurosurgery, and psychiatry · 2020Review
- Differential functional connectivity in thalamic and dopaminergic pathways in restless legs syndrome: a meta-analysis.Therapeutic advances in neurological disorders · 2020Article
- Natural biological variation of white matter microstructure is accentuated in Huntington's disease.Human brain mapping · 2018Article
- Reduced striato-cortical and inhibitory transcallosal connectivity in the motor circuit of Huntington's disease patients.Human brain mapping · 2018Article
- Good News or Bad News, Which Do You Want First? The Importance of the Sequence and Organization of Information for Financial Decision-Making: A Neuro-Electrical Imaging Study.Frontiers in human neuroscience · 2018Article
- Intact sensory-motor network structure and function in far from onset premanifest Huntington's disease.Scientific reports · 2017Article
- White matter predicts functional connectivity in premanifest Huntington's disease.Annals of clinical and translational neurology · 2017Article
- A Neuroelectrical Brain Imaging Study on the Perception of Figurative Paintings against Only their Color or Shape Contents.Frontiers in human neuroscience · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Huntington's disease, the relationship of brain structure, brain function and clinical measures remains incompletely understood. We asked how sensory-motor network brain structure and neural activity relate to each other and to motor performance. Thirty-four early stage HD and 32 age- and sex-matched healthy control participants underwent structural magnetic resonance imaging (MRI), diffusion tensor, and intrinsic functional connectivity MRI. Diffusivity patterns were assessed in the cortico-spinal tract and the thalamus-somatosensory cortex tract. For the motor network connectivity analyses the dominant M1 motor cortex region and for the basal ganglia-thalamic network the thalamus were used as seeds. Region to region structural and functional connectivity was examined between thalamus and somatosensory cortex. Fractional anisotropy (FA) was higher in HD than controls in the basal ganglia, and lower in the external and internal capsule, in the thalamus, and in subcortical white matter. Between-group axial and radial diffusivity differences were more prominent than differences in FA, and correlated with motor performance. Within the motor network, the insula was less connected in HD than in controls, with the degree of connection correlating with motor scores. The basal ganglia-thalamic network's connectivity differed in the insula and basal ganglia. Tract specific white matter diffusivity and functional connectivity were not correlated. In HD sensory-motor white matter organization and functional connectivity in a motor network were independently associated with motor performance. The lack of tract-specific association of structure and function suggests that functional adaptation to structural loss differs between participants.
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Registered trials
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