ArticlePsychopharmacology2016
When the party is over: depressive-like states in rats following termination of cortical D1 receptor overexpression.
Article in Psychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Dopamine, Immunity, and Disease.Pharmacological reviews · 2023Review
- Antidepressant-like effects of cinnamamide derivative M2 via DActa pharmacologica Sinica · 2022Article
- Prefrontal Dopaminergic Regulation of Cue-Guided Risky Decision-Making Performance in Rats.Frontiers in behavioral neuroscience · 2022Article
- Dysregulation of brain dopamine systems in major depressive disorder.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Prefrontal dopamine D1 receptor manipulation influences anxiety behavior and induces neuroinflammation within the hippocampus.International journal of bipolar disorders · 2021Article
- Risky decision-making following prefrontal D1 receptor manipulation.Translational neuroscience · 2021Article
- The use of laser capture microdissection to identify specific pathways and mechanisms involved in impulsive choice in rats.Heliyon · 2019Article
- Intra-individual variability in animal models of bipolar disorder.International journal of bipolar disorders · 2019Article
- Stress, sensitive periods, and substance abuse.Neurobiology of stress · 2019Review
- Antidepressant and pro-motivational effects of repeated lamotrigine treatment in a rat model of depressive symptoms.Heliyon · 2018Article
- Animal models for bipolar disorder: from bedside to the cage.International journal of bipolar disorders · 2017Review
- Divergent anomaly in mesocorticolimbic dopaminergic circuits might be associated with different depressive behaviors, an animal study.Brain and behavior · 2017Article
- Early life stress and later peer distress on depressive behavior in adolescent female rats: Effects of a novel intervention on GABA and D2 receptors.Behavioural brain research · 2017Article
- Sensitive periods of substance abuse: Early risk for the transition to dependence.Developmental cognitive neuroscience · 2017Review
- Test-retest measurements of dopamine DEuropean journal of nuclear medicine and molecular imaging · 2017Article
- Timing of amphetamine exposure in relation to puberty onset determines its effects on anhedonia, exploratory behavior, and dopamine DNeuroscience · 2016Article
- Commentary on the special issue on the adolescent brain: Adolescence, trajectories, and the importance of prevention.Neuroscience and biobehavioral reviews · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleIncreased activity of prefrontal D1 dopamine receptors (D1R) is involved in reward-related behavior found in bipolar disorder and drug addiction. While the effects of elevated D1R are known, depressive-like behaviors also occur in these disorders after reward-seeking ends.
objectivesThe goal is to characterize how termination of D1R overexpression influences depressive-like behaviors.
methodsAn inducible (Tet.On), lentiviral vector was used to manipulate the expression of the DRD1 gene in glutamate neurons within the prefrontal cortex in male, adult rats. Sexual activity and sucrose preference were studied in both D1R elevated ON and relatively reduced OFF states. Following termination of the D1R ON state, depressive-like behavior was determined in the OFF state. Expression of the transcriptional regulator, cyclic AMP-responsive element-binding protein (CREB), was used as an indication of downstream effects in the nucleus accumbens (NA).
resultsON D1R expression increased sexual activity that returned to baseline in the OFF state. Sucrose preferences increased ~6 % in ON state but fell 11 % below control levels when OFF. Consistent with a depressive-like phenotype, D1R OFF decreased activity by 40 %, impaired the ability to control (43 %) and motivation to escape shock (27 % more impaired) relative to dsRed OFF. CREB increased 29 % in the NA in the D1R OFF state relative to the ON state.
conclusionsThis novel approach demonstrates that elevated D1R expression increased hedonic behavior, whereas the termination of D1R overexpression often resulted in depressive-like behavior. These observations support a role for D1R expression cycling in bipolar-associated behaviors and addiction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.