Evidence map›Paper›PMID 26762282›Full record

Trial reportBMC complementary and alternative medicine2016

The effect of Sailuotong (SLT) on neurocognitive and cardiovascular function in healthy adults: a randomised, double-blind, placebo controlled crossover pilot trial.

Genevieve Z Steiner, Alan Yeung, Jian-Xun Liu, David A Camfield, Frances M de Blasio, Andrew Pipingas, Andrew B Scholey, Con Stough, Dennis H Chang

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC complementary and alternative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06228638 (CognivAiD Real-World Evidence Clinical Registry), which is not on this map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
9.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06228638 unknown statusnot on this mapstarted 2023, after this paper: background citation

CognivAiD Real-World Evidence Clinical Registry

Typeobservational_patient_registrySponsorMoleac Pte Ltd.Ran2023 to 2025Enrolled100ConditionsMemory Impairment, Dementia, VascularArmsCognivAID (Sailuotong)
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 37 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Safety and Efficacy of AlphaWaveNeurology and therapy · 2024
    Article
  4. Article
  5. Review
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  7. Article
  8. Review
  9. Combination ofFrontiers in pharmacology · 2022
    Article
  10. Review
  11. Article
  12. Review
  13. Endothelium-Independent Vasodilatory Effect of Sailuotong (SLT) on Rat Isolated Tail Artery.Evidence-based complementary and alternative medicine : eCAM · 2020
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine.Evidence-based complementary and alternative medicine : eCAM · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Genevieve Z SteinerNational Institute of Complementary Medicine, and School of Science and Health, Western Sydney University, Penrith, NSW 2751, Australia.
Alan YeungNational Institute of Complementary Medicine, and School of Science and Health, Western Sydney University, Penrith, NSW 2751, Australia.
Jian-Xun LiuXiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
David A CamfieldCentre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
Frances M de BlasioCentre for Psychophysics, Psychophysiology, and Psychopharmacology; Brain & Behaviour Research Institute; and School of Psychology, University of Wollongong, Wollongong, NSW 2522, Australia.
Andrew PipingasCentre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
Andrew B ScholeyCentre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
Con StoughCentre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
Dennis H ChangNational Institute of Complementary Medicine, and School of Science and Health, Western Sydney University, Penrith, NSW 2751, Australia. D.Chang@westernsydney.edu.au.
Swinburne University of Technology · AUWestern Sydney University · AUUniversity of Wollongong · AUXiyuan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSailuotong (SLT) is a standardised herbal medicine formula consisting of Panax ginseng, Ginkgo biloba, and Crocus sativus, and has been designed to enhance cognitive and cardiovascular function.

methodsUsing a randomised, double-blind, placebo controlled crossover design, this pilot study assessed the effect of treatment for 1 week with SLT and placebo (1 week washout period) on neurocognitive and cardiovascular function in healthy adults. Sixteen adults completed a computerised neuropsychological test battery (Compass), and had their electroencephalographic (EEG) activity and cardiovascular system function assessed. Primary outcome measures were cognitive test scores and oddball task event-related potential (ERP) component amplitudes. Secondary outcome measures were resting EEG spectral band amplitudes, and cardiovascular parameters.

resultsTreatment with SLT, compared to placebo, resulted in small improvements in working memory, a slight increase in auditory target (cf. nontarget) P3a amplitude, and a decrease in auditory N1 target (cf. nontarget) amplitude. There was no effect of SLT on EEG amplitude in delta, theta, alpha, or beta bands in both eyes open and eyes closed resting conditions, or on aortic and peripheral pulse pressure, and resting heartrate.

conclusionsFindings suggest that SLT has the potential to improve working memory performance in healthy adults; a larger sample size is needed to confirm this.

trial registrationAustralia New Zealand Clinical Trials Registry Trial Registration Id: ACTRN12610000947000 .

Indexed as

CrocusGinkgo bilobaPanaxAdultBlood PressureCognitionCross-Over StudiesDouble-Blind MethodDrug CombinationsFemaleHeart RateHumansMaleMiddle AgedPilot ProjectsPlants, MedicinalDrug Combinations

Identifiers

PMID26762282
PMCPMC4712609
OpenAlexW2238542003

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.