Evidence map›Paper›PMID 26761710›Full record

ArticlePloS one2016

Titanium Implant Impairment and Surrounding Muscle Cell Death Following High-Salt Diet: An In Vivo Study.

Mathieu Lecocq, Marie-Solenne Felix, Jean-Marc Linares, Julien Chaves-Jacob, Patrick Decherchi, Erick Dousset

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Mathieu LecocqAix-Marseille Université, CNRS, Institut des Sciences du Mouvement: Etienne-Jules MAREY (UMR 7287), Equipe « Plasticité des Systèmes Nerveux et Musculaire » (PSNM), Parc Scientifique et Technologique de Luminy, Faculté des Sciences du Sport de Marseille, CC910, 163, avenue de Luminy, 13288, Marseille Cedex 09, France.
Marie-Solenne FelixAix-Marseille Université, CNRS, Institut des Sciences du Mouvement: Etienne-Jules MAREY (UMR 7287), Equipe « Plasticité des Systèmes Nerveux et Musculaire » (PSNM), Parc Scientifique et Technologique de Luminy, Faculté des Sciences du Sport de Marseille, CC910, 163, avenue de Luminy, 13288, Marseille Cedex 09, France.
Jean-Marc LinaresAix-Marseille Université, CNRS, Institut des Sciences du Mouvement: Etienne-Jules MAREY (UMR 7287), Equipe « Conception Bio-Inspirée » (CBI), IUT d'Aix-Marseille, 413, avenue Gaston Berger, 13625, Aix-en-Provence Cedex, France.
Julien Chaves-JacobAix-Marseille Université, CNRS, Institut des Sciences du Mouvement: Etienne-Jules MAREY (UMR 7287), Equipe « Conception Bio-Inspirée » (CBI), IUT d'Aix-Marseille, 413, avenue Gaston Berger, 13625, Aix-en-Provence Cedex, France.
Patrick DecherchiAix-Marseille Université, CNRS, Institut des Sciences du Mouvement: Etienne-Jules MAREY (UMR 7287), Equipe « Plasticité des Systèmes Nerveux et Musculaire » (PSNM), Parc Scientifique et Technologique de Luminy, Faculté des Sciences du Sport de Marseille, CC910, 163, avenue de Luminy, 13288, Marseille Cedex 09, France.
Erick DoussetAix-Marseille Université, CNRS, Institut des Sciences du Mouvement: Etienne-Jules MAREY (UMR 7287), Equipe « Plasticité des Systèmes Nerveux et Musculaire » (PSNM), Parc Scientifique et Technologique de Luminy, Faculté des Sciences du Sport de Marseille, CC910, 163, avenue de Luminy, 13288, Marseille Cedex 09, France.
Institut des Sciences Moléculaires · FRCentre National de la Recherche Scientifique · FRAix-Marseille Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aim of the studyHigh-salt consumption has been widely described as a risk factor for cardiovascular, renal and bone functions. In the present study, the extent to which high-salt diet could influence Ti6Al4V implant surface characteristic, its adhesion to rat tibial crest, and could modify muscle cell viability of two surrounding muscles, was investigated in vivo. These parameters have also been assessed following a NMES (neuro-myoelectrostimulation) program similar to that currently used in human care following arthroplasty.

resultsAfter a three-week diet, a harmful effect on titanium implant surface and muscle cell viability was noted. This is probably due to salt corrosive effect on metal and then release of toxic substance around biologic tissue. Moreover, if the use of NMES with high-salt diet induced muscles damages, the latter were higher when implant was added. Unexpectedly, higher implant-to-bone adhesion was found for implanted animals receiving salt supplementation.

conclusionOur in vivo study highlights the potential dangerous effect of high-salt diet in arthroplasty based on titanium prosthesis. This effect appears to be more important when high-salt diet is combined with NMES.

Indexed as

Prostheses and ImplantsAlloysAnimalsArthroplastyBlood PressureCell SurvivalCoated Materials, BiocompatibleDietElectric StimulationMaleMusclesOsseointegrationProsthesis ImplantationRatsRats, Sprague-DawleyRisk FactorsAlloysCoated Materials, BiocompatibleSodium Chloride, DietaryTitaniumtitanium alloy (TiAl6V4)

Identifiers

PMID26761710
PMCPMC4711999
OpenAlexW2235524883

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.