ArticleJournal of acquired immune deficiency syndromes (1999)2016
Ten Years of Screening and Testing for Acute HIV Infection in North Carolina.
Article in Journal of acquired immune deficiency syndromes (1999), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Acute and early HIV infection screening among men who have sex with men, a systematic review and meta-analysis.Journal of the International AIDS Society · 2020Pooled it
- Human Immunodeficiency Virus (HIV)-1 Transmission Among Persons With Acute HIV-1 Infection in Malawi: Demographic, Behavioral, and Phylogenetic Relationships.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Trial
- Rapid viral suppression using integrase inhibitors during acute HIV-1 infection.The Journal of antimicrobial chemotherapy · 2025Article
- Sequence Analysis of Inducible, Replication-Competent Virus Reveals No Evidence of HIV-1 Evolution During Suppressive Antiviral Therapy, Indicating a Lack of Ongoing Viral Replication.Open forum infectious diseases · 2024Article
- HIV-1 Transmission linkages among persons with incident infection to inform public health surveillance.EClinicalMedicine · 2021Article
- Peer Mobilization and Human Immunodeficiency Virus (HIV) Partner Notification Services Among Gay, Bisexual, and Other Men Who Have Sex With Men and Transgender Women in Coastal Kenya Identified a High Number of Undiagnosed HIV Infections.Open forum infectious diseases · 2021Article
- Efficacy, pharmacokinetics and neurocognitive performance of dual, NRTI-sparing antiretroviral therapy in acute HIV-infection.AIDS (London, England) · 2020Article
- Correlates of ART Use Among Newly Diagnosed HIV Positive Adolescent Girls and Young Women Enrolled in HPTN 068.AIDS and behavior · 2020Article
- Why Everyone (Almost) with HIV Needs to Be on Treatment: A Review of the Critical Data.Infectious disease clinics of North America · 2019Review
- Postpartum HIV care continuum outcomes in the southeastern USA.AIDS (London, England) · 2019Article
- Pilot testing of an online training module about screening for acute HIV infection in adult patients seeking urgent healthcare.International health · 2019Article
- Viral Loads Within 6 Weeks After Diagnosis of HIV Infection in Early and Later Stages: Observational Study Using National Surveillance Data.JMIR public health and surveillance · 2018Article
- Universal Screening of Pregnant Women for Hepatitis C: The Time Is Now.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Repeat Human Immunodeficiency Virus Testing by Transmission Risk Group and Rurality of Residence in North Carolina.Sexually transmitted diseases · 2018Article
- Leveraging Phylogenetics to Understand HIV Transmission and Partner Notification Networks.Journal of acquired immune deficiency syndromes (1999) · 2018Article
- Integration of Contact Tracing and Phylogenetics in an Investigation of Acute HIV Infection.Sexually transmitted diseases · 2018Article
- Clinical and public health implications of acute and early HIV detection and treatment: a scoping review.Journal of the International AIDS Society · 2017Article
- Differences in Risk Behavior and Demographic Factors Between Men Who Have Sex With Men With Acute and Nonacute Human Immunodeficiency Virus Infection in a Community-Based Testing Program in Los Angeles.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- Fixed-dose combination emtricitabine/tenofovir/efavirenz initiated during acute HIV infection; 96-week efficacy and durability.AIDS (London, England) · 2016Article
- Performance of the BioPlex 2200 HIV Ag-Ab assay for identifying acute HIV infection.Journal of clinical virology : the official publication of the Pan American Society for Clinical VirologyArticle
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo describe demographic and behavioral characteristics of persons with acute HIV infection (AHI) over time.
methodsWe conducted a retrospective assessment of AHI identified through the Screening and Tracing Active Transmission (STAT) program from 2003 to 2012 in North Carolina (NC). AHI was identified using pooled nucleic acid amplification for antibody negative samples and individual HIV-1 RNA for antibody indeterminate samples. The STAT program provides rapid notification and evaluation. We compared STAT-collected demographic and risk characteristics with all persons requesting tests and all non-AHI diagnoses from the NC State Laboratory of Public Health.
resultsThe STAT Program identified 236 AHI cases representing 3.4% (95% confidence interval: 3.0% to 3.9%) of all HIV diagnoses. AHI cases were similar to those diagnosed during established HIV. On pretest risk-assessments, AHI cases were predominately black (69.1%), male (80.1%), young (46.8% < 25 years), and men who have sex with men (MSM) (51.7%). Per postdiagnosis interviews, the median age decreased from 35 (interquartile range 25-42) to 27 (interquartile range 22-37) years, and the proportion <25 years increased from 23.8% to 45.2% (trend P = 0.04) between 2003 and 2012. AHI men were more likely to report MSM risk post-diagnosis than on pretest risk-assessments (64%-82.9%; P < 0.0001). Post-diagnosis report of MSM risk in men with AHI increased from 71.4% to 96.2%.
conclusionsIn NC, 3.4% of individuals diagnosed with HIV infection have AHI. AHI screening provides a real-time source of incidence trends, improves the diagnostic yield of HIV testing, and offers an opportunity to limit onward transmission.
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Registered trials
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