Trial reportJournal of acquired immune deficiency syndromes (1999)2016
Effective Treatment of Depressive Disorders in Medical Clinics for Adolescents and Young Adults Living With HIV: A Controlled Trial.
Trial report in Journal of acquired immune deficiency syndromes (1999), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02939131 (IMPAACT 2002), which is not on this map. Cited by 26 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
IMPAACT 2002: Combined Cognitive Behavioral Therapy and a Medication Management Algorithm for Treatment of Depression Among Youth Living With HIV in the United States
Who cites it
26 citing papers in PubMed, 6 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Systematic review and meta-analysis of psychological interventions for depression symptoms in young people with long-term physical health conditions.Journal of pediatric psychology · 2025Pooled it
- Evidence from high-income countries on the effectiveness of psychosocial interventions to improve mental health, wellbeing and quality of life for adults living with HIV: a systematic review and meta-analysis.Journal of the International AIDS Society · 2025Pooled it
- Depressive Symptoms and HIV Viral Suppression: A Systematic Review and Meta-analysis.AIDS and behavior · 2025Pooled it
- Psychosocial interventions for improving engagement in care and health and behavioural outcomes for adolescents and young people living with HIV: a systematic review and meta-analysis.Journal of the International AIDS Society · 2021Pooled it
- Psychological therapies for anxiety and depression in children and adolescents with long-term physical conditions.The Cochrane database of systematic reviews · 2018Pooled it
- Antidepressants for depression in adults with HIV infection.The Cochrane database of systematic reviews · 2018Pooled it
- Use of a Medication Management Algorithm in Depressed Youth Living with HIV: Secondary Analysis of a Multisite Randomized Controlled Trial.Journal of child and adolescent psychopharmacology · 2026Trial
- Effect of the Friendship Bench Intervention on Antiretroviral Therapy Outcomes and Mental Health Symptoms in Rural Zimbabwe: A Cluster Randomized Trial.JAMA network open · 2023Trial
- Site-Randomized Controlled Trial of a Combined Cognitive Behavioral Therapy and a Medication Management Algorithm for Treatment of Depression Among Youth Living With HIV in the United States.Journal of acquired immune deficiency syndromes (1999) · 2021Trial
- A group-based mental health intervention for young people living with HIV in Tanzania: results of a pilot individually randomized group treatment trial.BMC public health · 2020Trial
- A hybrid type 2 cluster randomized trial of an enhanced combined cognitive behavioral therapy and medication management algorithm for treatment of depression among youth living with HIV: study protocol.Implementation science : IS · 2026Article
- Comprehensive Communication for a Syndemic Approach to HIV Care: A Framework for Enhancing Health Communication Messages for People Living with HIV.International journal of environmental research and public health · 2025Review
- Cognitive behavioral therapy for antiretroviral therapy adherence and treatment outcomes among people living with HIV: a systematic review and meta-analysis.Nature. Mental health · 2025Article
- The Impact of Group-Based Interventions on Emotional and Behavioral Difficulties among Adolescents Living with HIV: The Suubi4Stigma Cluster Randomized Controlled Trial.Journal of child and family studies · 2025Article
- Family Support and Depression among Adolescents Living with HIV in Northern Nigeria.Current HIV research · 2025Article
- Perceived barriers and opportunities for implementing an integrated psychological intervention for depression in adolescents living with HIV in Tanzania.BMC health services research · 2024Article
- An mHealth Intervention to Address Depression and Improve Antiretroviral Therapy Adherence Among Youths Living With HIV in Uganda: Protocol for a Pilot Randomized Controlled Trial.JMIR research protocols · 2024Article
- Integrating Adolescent Mental Health into HIV Prevention and Treatment Programs: Can Implementation Science Pave the Path Forward?AIDS and behavior · 2023Article
- Effect of the Friendship Bench intervention on antiretroviral therapy outcomes and mental health symptoms in rural Zimbabwe: A cluster randomized trial.medRxiv : the preprint server for health sciences · 2023Article
- A Review of Interventions to Enhance HIV Medication Adherence.Current HIV/AIDS reports · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 7 institutions in 1 country.
Funding
Abstract
objectivePreliminary test of a manualized, measurement-guided treatment for depression for adolescents and young adults in care at 4 sites of the Adolescent Trials Network for HIV/AIDS Interventions.
designThe US sites were randomly assigned to either a 24-week, combination cognitive behavioral therapy and medication management algorithm (COMB) tailored for youth living with HIV (YLWH) or to treatment as usual (TAU).
methodsYouth at TAU sites had access to therapists and medication management as needed. COMB-site clinicians were trained in the manualized intervention and participated in supervision calls to monitor intervention fidelity.
resultsOver the course of the study with 44 participants, those in COMB, compared with those in TAU, reported fewer depressive symptoms, P < 0.01 (as measured by the Quick Inventory for Depression symptoms) and were more likely to be in remission, P < 0.001 (65% vs. 10% at week 24, end of treatment, and 71% vs. 7% at week 48, final follow-up). A greater proportion of COMB participants received psychotherapy (95% vs. 45%, P < 0.001) and attended more sessions (12.6 vs. 5, P < 0.001) than those in TAU. Viral load decreased in both groups and was associated (P < 0.05) with reduction in depressive symptoms.
conclusionsA 24-week manualized, measurement-guided psychotherapy and medication management algorithm tailored for YLWH was more effective in achieving and sustaining remission from depression than TAU at HIV care clinic sites. Given observed treatment efficacy, this structured combination treatment could be disseminated to medical clinics to successfully treat YLWH, who are at particular risk for depression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.