ReviewInternational journal of molecular sciences2016
Regulatory System for Stem/Progenitor Cell Niches in the Adult Rodent Pituitary.
Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- CD9/SOX2-positive cells in the intermediate lobe of the rat pituitary gland exhibit mesenchymal stem cell characteristics.Cell and tissue research · 2025Article
- Three-dimensional cell culture using CD9-positive cells isolated from marginal cell layer of intermediate lobe of rats sustains in vivo-like primary niche environment.The Journal of reproduction and development · 2024Article
- Expression and localization of tight junction-related proteins in adult rat pituitary stem/progenitor cell niches.The Journal of reproduction and development · 2022Article
- Architects of Pituitary Tumour Growth.Frontiers in endocrinology · 2022Review
- CD9-positive cells in the intermediate lobe migrate into the anterior lobe to supply endocrine cells.Histochemistry and cell biology · 2021Article
- Localization of putative pituitary stem/progenitor cells in female dairy cattle.The Journal of veterinary medical science · 2021Article
- Heterogeneity and Dynamics of Vasculature in the Endocrine System During Aging and Disease.Frontiers in physiology · 2021Review
- Experimental Evidence and Clinical Implications of Pituitary Adenoma Stem Cells.Frontiers in endocrinology · 2020Review
- Regulation and function of neurogenesis in the adult mammalian hypothalamus.Progress in neurobiology · 2018Review
- Localization of SOX2-positive stem/progenitor cells in the anterior lobe of the common marmoset (Callithrix jacchus) pituitary.The Journal of reproduction and development · 2018Article
- Isolation and characterisation of CD9-positive pituitary adult stem/progenitor cells in rats.Scientific reports · 2018Article
- Expression and localization of forkhead box protein FOXJ1 in S100β-positive multiciliated cells of the rat pituitary.Medical molecular morphology · 2017Article
- Regulation of pituitary stem cells by epithelial to mesenchymal transition events and signaling pathways.Molecular and cellular endocrinology · 2017Review
- Involvement of DNA methylation in regulating rat Prop1 gene expression during pituitary organogenesis.The Journal of reproduction and development · 2017Article
- Stem Cell Activation in Adult Organisms.International journal of molecular sciences · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The anterior lobe of the pituitary gland is a master endocrine tissue composed of five types of endocrine cells. Although the turnover rate of pituitary endocrine cells is as low as about 1.6% per day, recent studies have demonstrated that Sex-determining region Y-box 2 (SOX2)⁺-cells exist as pituitary stem/progenitor cells in the adult anterior lobe and contribute to cell regeneration. Notably, SOX2⁺-pituitary stem/progenitor cells form two types of niches in this tissue: the marginal cell layer (MCL-niche) and the dense cell clusters scattering in the parenchyma (parenchymal-niche). However, little is known about the mechanisms and factors for regulating the pituitary stem/progenitor cell niches, as well as the functional differences between the two types of niches. Elucidation of the regulatory mechanisms in the niches might enable us to understand the cell regeneration system that acts in accordance with physiological demands in the adult pituitary. In this review, so as to reveal the regulatory mechanisms of the two types of niche, we summarize the regulatory factors and their roles in the adult rodent pituitary niches by focusing on three components: soluble factors, cell surface proteins and extracellular matrixes.
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