ArticlePloS one2016
Genotyping Yersinia pestis in Historical Plague: Evidence for Long-Term Persistence of Y. pestis in Europe from the 14th to the 17th Century.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 61 citations in OpenAlex.
- The plague of 1720 and migration in Martigues (France) in the 17th and 18th centuries.PloS one · 2026Article
- The Natural and Clinical History of Plague: From the Ancient Pandemics to Modern Insights.Microorganisms · 2024Review
- Role of meteorological parameters with the spread of Covid-19 in Pakistan: application of autoregressive distributed lag approach.International journal of environmental science and technology : IJEST · 2023Article
- Genetic source tracking of human plague cases in Inner Mongolia-Beijing, 2019.PLoS neglected tropical diseases · 2021Article
- CaptureSeq: Hybridization-Based Enrichment ofMicroorganisms · 2021Article
- Evolution and circulation of Yersinia pestis in the Northern Caspian and Northern Aral Sea regions in the 20th-21st centuries.PloS one · 2021Article
- Yersinia pestis: the Natural History of Plague.Clinical microbiology reviews · 2020Review
- New ancient Eastern EuropeanPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Ancient dental pulp: Masterpiece tissue for paleomicrobiology.Molecular genetics & genomic medicine · 2020Review
- Mortality and demographic recovery in early post-black death epidemics: Role of recent emigrants in medieval Dijon.PloS one · 2020Article
- Past pandemics and climate variability across the Mediterranean.Euro-Mediterranean journal for environmental integration · 2020Article
- Pandemics Throughout History.Frontiers in microbiology · 2020Review
- Phylogeography of the second plague pandemic revealed through analysis of historical Yersinia pestis genomes.Nature communications · 2019Article
- Looking Backward To Move Forward: the Utility of Sequencing Historical Bacterial Genomes.Journal of clinical microbiology · 2019Review
- AncientProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Ancient pathogen genomics as an emerging tool for infectious disease research.Nature reviews. Genetics · 2019Review
- Yersinia pestis and plague: an updated view on evolution, virulence determinants, immune subversion, vaccination, and diagnostics.Genes and immunity · 2019Review
- Phylogeny and Classification ofFrontiers in microbiology · 2018Article
- Comprehensive analysis of microorganisms accompanying human archaeological remains.GigaScience · 2017Article
- Mechanism study on a plague outbreak driven by the construction of a large reservoir in southwest china (surveillance from 2000-2015).PLoS neglected tropical diseases · 2017Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ancient DNA (aDNA) recovered from plague victims of the second plague pandemic (14th to 17th century), excavated from two different burial sites in Germany, and spanning a time period of more than 300 years, was characterized using single nucleotide polymorphism (SNP) analysis. Of 30 tested skeletons 8 were positive for Yersinia pestis-specific nucleic acid, as determined by qPCR targeting the pla gene. In one individual (MP-19-II), the pla copy number in DNA extracted from tooth pulp was as high as 700 gene copies/μl, indicating severe generalized infection. All positive individuals were identical in all 16 SNP positions, separating phylogenetic branches within nodes N07_N10 (14 SNPs), N07_N08 (SNP s19) and N06_N07 (s545), and were highly similar to previously investigated plague victims from other European countries. Thus, beside the assumed continuous reintroduction of Y. pestis from central Asia in multiple waves during the second pandemic, long-term persistence of Y. pestis in Europe in a yet unknown reservoir host has also to be considered.
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