ArticlePloS one2016
Production of Biologically Active Cecropin A Peptide in Rice Seed Oil Bodies.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Antimicrobial Peptides as Novel Ecological Approaches to Caries Prevention.Drug design, development and therapy · 2026Review
- High yield production of the antifungal proteins PeAfpA and PdAfpB by vacuole targeting in a TMV-based expression vector.Plant biotechnology journal · 2026Article
- Microbial Metabolites: A Sustainable Approach to Combat Plant Pests.Metabolites · 2025Review
- Co-expression of four penaeidins in transgenic rice seeds: an alternative strategy for substitute antibiotic agricultural products.Transgenic research · 2023Article
- Application of antimicrobial peptides in plant protection: making use of the overlooked merits.Frontiers in plant science · 2023Review
- Economic purification of recombinant uricase by artificial oil bodies.Bioresources and bioprocessing · 2022Article
- Review
- Efficient production of antifungal proteins in plants using a new transient expression vector derived from tobacco mosaic virus.Plant biotechnology journal · 2019Article
- Biotechnological Production of the Cell Penetrating Antifungal PAF102 Peptide inFrontiers in microbiology · 2019Article
- Rice Seeds as Biofactories of Rationally Designed and Cell-Penetrating Antifungal PAF Peptides.Frontiers in plant science · 2019Article
- Plant Lipid Droplets and Their Associated Proteins: Potential for Rapid Advances.Plant physiology · 2018Review
- The Road from Host-Defense Peptides to a New Generation of Antimicrobial Drugs.Molecules (Basel, Switzerland) · 2018Review
- Production of BP178, a derivative of the synthetic antibacterial peptide BP100, in the rice seed endosperm.BMC plant biology · 2017Article
- Hepatoprotective effects of rice-derived peptides against acetaminophen-induced damage in mice.Journal of clinical biochemistry and nutrition · 2017Article
- Recombinant production of antimicrobial peptides in plants.Biotechnology advancesReview
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cecropin A is a natural antimicrobial peptide that exhibits fast and potent activity against a broad spectrum of pathogens and neoplastic cells, and that has important biotechnological applications. However, cecropin A exploitation, as for other antimicrobial peptides, is limited by their production and purification costs. Here, we report the efficient production of this bioactive peptide in rice bran using the rice oleosin 18 as a carrier protein. High cecropin A levels were reached in rice seeds driving the expression of the chimeric gene by the strong embryo-specific oleosin 18 own promoter, and targeting the peptide to the oil body organelle as an oleosin 18-cecropin A fusion protein. The accumulation of cecropin A in oil bodies had no deleterious effects on seed viability and seedling growth, as well as on seed yield. We also show that biologically active cecropin A can be easily purified from the transgenic rice seeds by homogenization and simple flotation centrifugation methods. Our results demonstrate that the oleosin fusion technology is suitable for the production of cecropin A in rice seeds, which can potentially be extended to other antimicrobial peptides to assist their exploitation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.