Evidence map›Paper›PMID 26760715›Full record

ArticleEnvironment international2016

Concentrations of phthalates and DINCH metabolites in pooled urine from Queensland, Australia.

M J Gomez Ramos, A L Heffernan, L M L Toms, A M Calafat, X Ye, P Hobson, S Broomhall, J F Mueller

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Plasticizers: negative impacts on the thyroid hormone system.Environmental science and pollution research international · 2022
    Review
  5. Article
  6. Article
  7. Article
  8. Determination of Varying Group Sizes for Pooling Procedure.Computational and mathematical methods in medicine · 2019
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

M J Gomez RamosNational Research Centre for Environmental Toxicology, University of Queensland, Brisbane, QLD, Australia. Electronic address: m.gomezramos@uq.edu.au.
A L HeffernanNational Research Centre for Environmental Toxicology, University of Queensland, Brisbane, QLD, Australia. Electronic address: amy.heffernan@uqconnect.edu.au.
L M L TomsQueensland University of Technology, School of Public Health and Social Work, Brisbane, QLD, Australia; Queensland University of Technology, Institute of Health and Biomedical Innovation, Brisbane, QLD, Australia. Electronic address: leisamaree.toms@qut.edu.au.
A M CalafatCenters for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: aic7@cdc.gov.
X YeCenters for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: xay5@cdc.gov.
P HobsonSullivan Nicolaides Pathology, Taringa, QLD, Australia. Electronic address: Peter_Hobson@snp.com.au.
S BroomhallAustralian Government Department of the Environment, Canberra, ACT, Australia. Electronic address: Sara.Broomhall@environment.gov.au.
J F MuellerNational Research Centre for Environmental Toxicology, University of Queensland, Brisbane, QLD, Australia. Electronic address: j.mueller@uq.edu.au.
University of Queensland · AUCenters for Disease Control and Prevention · USAustralian Government · AUQueensland University of Technology · AUSullivan Nicolaides Pathology · AU

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

Dialkyl phthalate esters (phthalates) are ubiquitous chemicals used extensively as plasticizers, solvents and adhesives in a range of industrial and consumer products. 1,2-Cyclohexane dicarboxylic acid, diisononyl ester (DINCH) is a phthalate alternative introduced due to a more favourable toxicological profile, but exposure is largely uncharacterised. The aim of this study was to provide the first assessment of exposure to phthalates and DINCH in the general Australian population. De-identified urine specimens stratified by age and sex were obtained from a community-based pathology laboratory and pooled (n=24 pools of 100). Concentrations of free and total species were measured using online solid phase extraction isotope dilution high performance liquid chromatography tandem mass spectrometry. Concentrations ranged from 2.4 to 71.9ng/mL for metabolites of di(2-ethylhexyl)phthalate, and from <0.5 to 775ng/mL for all other metabolites. Our data suggest that phthalate metabolites concentrations in Australia were at least two times higher than in the United States and Germany; and may be related to legislative differences among countries. DINCH metabolite concentrations were comparatively low and consistent with the limited data available. Ongoing biomonitoring among the general Australian population may help assess temporal trends in exposure and assess the effectiveness of actions aimed at reducing exposures.

Indexed as

Environmental ExposureAdolescentAdultAgedAged, 80 and overChildChild, PreschoolCyclohexanecarboxylic AcidsDicarboxylic AcidsEnvironmental MonitoringEnvironmental PollutantsEstersFemaleHumansInfantInfant, NewbornCyclohexanecarboxylic AcidsDicarboxylic Acidsdiisononyl 1,2-cyclohexanedicarboxylic acidEnvironmental PollutantsEstersPhthalic AcidsAustraliaBiomonitoringChildrenDINCHPhthalatesPlasticizersPopulation monitoringUrine

Identifiers

PMID26760715
PMCPMC7957829
OpenAlexW2222391199

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.