ArticleTransplantation2016
Kidney Donor Profile Index Does Not Accurately Predict the Graft Survival of Pediatric Deceased Donor Kidneys.
Article in Transplantation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Characteristics of compatible pair participants in kidney paired donation at a single center.Clinical transplantation · 2017Trial
- Allocation of Kidney Allografts From Donors With Kidney Donor Profile Index <35% and the Impact of Kidney Donor Profile Index Revisions on Access to Transplantation for Children.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2026Article
- An In-depth overview of artificial intelligence (AI) tool utilization across diverse phases of organ transplantation.Journal of translational medicine · 2025Review
- En-bloc kidney transplants from very small pediatric donors: a propensity score matched analysis.Frontiers in pediatrics · 2025Article
- Prediction of allograft function in pre-transplant kidneys using sound touch elastography (STE): an ex vivo study.Insights into imaging · 2024Article
- A modified Kidney Donor Risk Index for pediatric kidney transplant recipients.Pediatric nephrology (Berlin, Germany) · 2023Article
- The UK kidney donor risk index poorly predicts long-term transplant survival in paediatric kidney transplant recipients.Frontiers in immunology · 2023Article
- A Review of Current and Emerging Trends in Donor Graft-Quality Assessment Techniques.Journal of clinical medicine · 2022Review
- Predictors and one-year outcomes of patients with delayed graft function after deceased donor kidney transplantation.BMC nephrology · 2020Article
- Pediatric deceased donor kidney transplant outcomes under the Kidney Allocation System.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019Article
- Assessing the discrimination of the Kidney Donor Risk Index/Kidney Donor Profile Index scores for allograft failure and estimated glomerular filtration rate in Ireland's National Kidney Transplant Programme.Clinical kidney journal · 2019Article
- Reevaluation of the Kidney Donor Risk Index.Transplantation · 2019Article
- Non-immunologic allograft loss in pediatric kidney transplant recipients.Pediatric nephrology (Berlin, Germany) · 2019Review
- R Open Source Programming Code for Calculation of the Kidney Donor Profile Index and Kidney Donor Risk Index.Kidney diseases (Basel, Switzerland) · 2018Article
- It is time to revise the kidney allocation system to restore the pediatric advantage.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018Article
- Impact of the kidney allocation system on young pediatric recipients.Clinical transplantation · 2018Article
- The kidney allocation system does not appropriately stratify risk of pediatric donor kidneys: Implications for pediatric recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018Article
- Kidney Donor Profile Index Does Not Accurately Predict the Graft Survival of Pediatric Deceased Donor Kidneys.Transplantation · 2016Article
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3 authors.
Funding
Abstract
backgroundThe new deceased donor kidney allocation algorithm uses a Kidney Donor Profile Index (KDPI) based on donor characteristics to predict graft survival and divides kidneys into 4 quality groups (ie, KDPI-A, -B, -C, and -D). Pediatric kidneys constitute 10% to 12% of deceased donor kidneys. We hypothesized that KDPI would not accurately predict pediatric donor graft survival and superior predictive models could be created.
methodsScientific Registry of Transplant Recipients data for years 2000 to 2010 for transplants from child (<10 years) and adolescent (10-17 years inclusive) donors into first-time adult recipients were analyzed with graft failure as the principle outcome. Two novel indices, Child Donor Index (CDI) and Adolescent Donor Index (ADI), were developed using stepwise variable deletion to identify significant model covariates in a Cox Regression. Pediatric donor kidneys were then classified into the 4 quality groups based on both KDPI and CDI/ADI scores. The performance of the KDPI, CDI, and ADI models were compared with respect to the 4 quality groups defined by the new allocation system.
resultsThe KDPI did not effectively discriminate between quality groups (P > 0.05 for all but 1 comparison) in Kaplan-Meier survival analyses. The CDI and ADI included novel variables (eg, body mass index percentiles) and successfully discriminated between quality groups (P < 0.05 by log rank test). The Net Reclassification Index showed improvement when switching from KDPI to CDI and ADI, with values of 0.09 (P < 0.001) and 0.073 (P < 0.001), respectively.
conclusionsThe KDPI does not accurately predict pediatric kidney graft survival. Alternative indices can improve allocation efficiency.
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