Evidence map›Paper›PMID 26760452›Full record

Trial reportAIDS (London, England)2016

Short message service (SMS) reminders and real-time adherence monitoring improve antiretroviral therapy adherence in rural Uganda.

Jessica E Haberer, Angella Musiimenta, Esther C Atukunda, Nicholas Musinguzi, Monique A Wyatt, Norma C Ware, David R Bangsberg

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AIDS (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 103 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04119375 nacompletednot on this mapstarted 2018, after this paper: background citation

Behavior Change and Digital Health Interventions for Improved TB Treatment Outcomes: a RCT

TypeinterventionalSponsorMassachusetts Institute of TechnologyRan2018 to 2021Enrolled16,146ConditionsTuberculosis, Adherence, Patient, Adherence, Medication, Drug-resistant TuberculosisArmsKeheala Mobile Health Platform and Behavioral Interventions, Social and Behavior Change Communication (SBCC), SMS Reminder, Standard of Care
NCT05656287 naunknown statusnot on this mapstarted 2022, after this paper: background citation

My Mobile Wallet: An Intervention to Support Access to Tuberculosis Care and Medication Adherence in Rural Uganda

TypeinterventionalSponsorMbarara University of Science and TechnologyRan2022 to 2026Enrolled242ConditionsTuberculosisArmsSMS texts + incentives + Wisepill device for medication monitoring, SMS texts only + Wisepill device for medication monitoring, Wisepill device for medication monitoring only
3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jessica E HabereraMassachusetts General Hospital, Boston bHarvard Medical School, Boston, Massachusetts, USA cMbarara University of Science and Technology, Mbarara, Uganda dHarvard TH Chan School of Public Health, Boston, Massachusetts, USA.
Angella Musiimenta
Esther C Atukunda
Nicholas Musinguzi
Monique A Wyatt
Norma C Ware
David R Bangsberg

Funding

Development of Real-Time Antiretroviral Therapy Adherence Intervention in UgandaR34MH100940 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI HABERER, JESSICA ELIZABETH · 2013 to 2015
$593k
NIMH NIH HHS R34 MH100940
6 · The paper itself

Abstract

objectiveTo explore the effects of four types of short message service (SMS) plus real-time adherence monitoring on antiretroviral therapy (ART) adherence: daily reminders, weekly reminders, reminders triggered after a late or missed dose (delivered to patients), and notifications triggered by sustained adherence lapses (delivered to patient-nominated social supporters).

designPilot randomized controlled trial.

methodsSixty-three individuals initiating ART received a real-time adherence monitor and were randomized (1 : 1 : 1): (1) Scheduled SMS reminders (daily for 1 month, weekly for 2 months), then SMS reminders triggered by a late or missed dose (no monitoring signal within 2 h of expected dosing); SMS notifications to social supporters for sustained adherence lapses (no monitoring signal for >48 h) added after 3 months. (2) Triggered SMS reminders starting at enrolment; SMS notifications to social supporters added after 3 months. (3) CONTROL: No SMS. HIV RNA was determined at 9 months. Percentage adherence and adherence lapses were compared by linear generalized estimating equations and Poisson regression, respectively.

resultsMedian age was 31 years, 65% were women, and median enrolment CD4 cell count was 322 cells/μl 97% took once daily tenofovir/emtricitabine/efavirenz. Compared to control, adherence was 11.1% higher (P = 0.04) and more than 48-h lapses were less frequent (IRR 0.6, P = 0.02) in the scheduled SMS arm. Adherence and more than 48-h lapses were similar in the triggered SMS arm and control. No differences in HIV RNA were seen.

conclusionScheduled SMS reminders improved ART in the context of real-time monitoring. Larger studies are needed to determine the impact of triggered reminders and role of social supporters in improving adherence.

Indexed as

Reminder SystemsText MessagingAdultAnti-Retroviral AgentsFemaleHIV InfectionsHumansMaleMedication AdherenceMiddle AgedPilot ProjectsRural PopulationUgandaAnti-Retroviral Agents

Identifiers

PMID26760452
PMCPMC4851578

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.