Evidence map›Paper›PMID 26760235›Full record

ArticleAIDS (London, England)2016

Placental transfer of anti-group B Streptococcus immunoglobulin G antibody subclasses from HIV-infected and uninfected women to their uninfected infants.

Kirsty Le Doare, Stephen Taylor, Lauren Allen, Andrew Gorringe, Paul T Heath, Beate Kampmann, Anneke C Hesseling, Christine E Jones

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  6. Review
  7. Article
  8. Review
  9. Meningococcal vaccination in pregnancy.Human vaccines & immunotherapeutics · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kirsty Le DoareaCentre for International Child Health and Department of Academic Paediatrics, Imperial College, London bPaediatric Infectious Diseases Research Group, Institute for Infection and Immunity St George's, University of London, London, UK cVaccines and Immunity Theme, Medical Research Council Unit, Fajara, The Gambia dPublic Health England, Porton Down, Salisbury, UK eDepartment of Pediatrics and Child Health, Desmond Tutu TB Center, Stellenbosch University fInstitute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Stephen Taylor
Lauren Allen
Andrew Gorringe
Paul T Heath
Beate Kampmann
Anneke C Hesseling
Christine E Jones
Desmond Tutu HIV Foundation · ZA

Funding

Medical Research Council MC_UP_A900/1122Medical Research Council MC_UP_A900_1122Medical Research Council MR/K007602/1Wellcome Trust 100693Wellcome Trust KLD2013
6 · The paper itself

Abstract

objectivesPlacental antibody transfer is impaired in the context of HIV infection, which may render HIV-exposed, uninfected infants vulnerable to group B Streptococcus (GBS) disease. The GBS antibody response predominately consists of immunoglobulin G2 (IgG2) antibody. Thus we determined whether concentration and placental transfer of anti-GBS antibody subclasses was altered in HIV-infected compared with HIV-uninfected mothers.

designA retrospective analysis of anti-GBS antibody subclasses in 38 HIV-infected and 33 HIV-uninfected mothers and their uninfected infants.

methodsSera were analysed using a novel flow cytometric assay that quantified binding of IgG1, IgG2, IgG3 and IgG4 to serotype (ST)Ia, STIII and STV GBS bacteria.

resultsIgG2 binding to GBS STIa and V was lower in HIV-infected women compared with HIV-uninfected women. Moreover, IgG2 binding to GBS STIa was also lower in HIV-exposed, uninfected infants compared with unexposed infants. However, there were no statistically significant differences in the transplacental transfer ratio of IgG2 for any GBS serotype. The transplacental transfer of total IgG was reduced for GBS STIII and V and IgG1 subclass for STIII; placental transfer of all other subclasses was comparable in HIV-affected and HIV-unaffected pregnancies.

conclusionAnti-GBS IgG2 placental transfer is not affected by HIV infection. This is important for functional antibody against the capsular polysaccharide of GBS and provides confidence that maternal GBS vaccination may result in functional activity in HIV-infected and uninfected women.

Indexed as

Immunity, Maternally-AcquiredAntibodies, BacterialFemaleHIV InfectionsHumansImmunoglobulin GInfantInfant, NewbornPregnancyPregnancy Complications, InfectiousRetrospective StudiesStreptococcus agalactiaeAntibodies, BacterialImmunoglobulin G

Identifiers

PMID26760235
PMCPMC4711380
OpenAlexW2213573044

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.