Observational studyAIDS (London, England)2016
Long-term impact of HIV wasting on physical function.
Observational study in AIDS (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Prevalence and associated factors of malnutrition among adults living with HIV on ART: a pilot study.Metabolism open · 2026Article
- A bibliometric mapping study of the literature on the quality of life of people living with HIV.AIDS research and therapy · 2025Article
- Chronic diarrhoea in a human immunodeficiency virus/acquired immunodeficiency syndrome patient: A case report.World journal of virology · 2025Article
- Impact of Body Mass Index and VO2 Max on Symptoms, Physical Activity, and Physical Function in a Multinational Sample of People with HIV.AIDS and behavior · 2025Article
- Anthropometric measurements as predictors of nutritional status in black South African women during pregnancy.The journal of obstetrics and gynaecology research · 2025Observational
- Use of the Patient Generated Index to Identify Physical Health Challenges Among People Living with HIV: A Cross-Sectional Study.Physiotherapy Canada. Physiotherapie Canada · 2024Article
- Expert Consensus Statement on an Updated Definition of Unintended Weight Loss Among Persons With Human Immunodeficiency Virus in the Modern Treatment Era.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Review
- Non-communicable disease risk factors among people living with HIV/AIDS (PLHA) - A relook during the covid-19 pandemic.Journal of family medicine and primary care · 2022Article
- Levels and correlates of physical activity and capacity among HIV-infected compared to HIV-uninfected individuals.PloS one · 2022Article
- Relationship Between Handgrip Strength and Age in the Body Composition Variables Among People Living with HIV.Current HIV research · 2022Article
- Mitochondrial DNA Haplogroups and Frailty in Adults Living with HIV.AIDS research and human retroviruses · 2020Observational
- Koala retrovirus viral load and disease burden in distinct northern and southern koala populations.Scientific reports · 2020Article
- Epigenomic mechanisms of alcohol-induced impaired differentiation of skeletal muscle stem cells; role of Class IIA histone deacetylases.Physiological genomics · 2019Article
- Diminished physical function in older HIV-infected adults in the Southeastern U.S. despite successful antiretroviral therapy.PloS one · 2017Article
- Disease drivers of aging.Annals of the New York Academy of Sciences · 2016Review
- Long-term body composition changes in antiretroviral-treated HIV-infected individuals.AIDS (London, England) · 2016Observational
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe long-term consequences of wasting among HIV-infected persons are not known.
designHIV-infected men surviving ≥2 years based on Kaplan-Meier analysis after a clinical diagnosis or weight trajectory consistent with wasting and with available physical function assessment data [grip strength, gait speed, and quality of life (QoL)] were matched to HIV-infected and uninfected men without wasting.
methodsMatching criteria at the functional assessment included age, calendar year, and CD4 T-cell count and plasma HIV-1 RNA (HIV-infected only). Multivariable linear regression analyses adjusted for age, cohort, race, hepatitis C status, and number of comorbid illnesses were used to assess the impact of wasting on subsequent physical function.
resultsAmong 85 HIV-infected men surviving ≥2 years after wasting, we evaluated physical function outcomes compared with 249 HIV-infected and 338 HIV-uninfected men with no historical wasting. In multivariable regression models, HIV-infected men with prior wasting had lower grip strength and poorer physical QoL than HIV-infected men with no wasting (P ≤ 0.03), and poorer physical QoL, but higher mental QoL than HIV-uninfected men (P ≤ 0.05). When controlling for measures of immune suppression (nadir CD4 T-cell count/AIDS, the association between wasting and physical QoL was markedly attenuated, whereas there was minimal impact on the association between wasting and grip strength.
conclusionsHIV-infected wasting survivors had weaker grip strength compared with HIV-infected persons without wasting; immune suppression was associated only with physical QoL. HIV-infected survivors of wasting may represent a population of adults at increased risk for physical function decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.