Evidence map›Paper›PMID 26760177›Full record

Observational studyThe Journal of clinical endocrinology and metabolism2016

Diabetes, Diabetes Treatment, and Risk of Thyroid Cancer.

Juhua Luo, Lawrence Phillips, Simin Liu, Jean Wactawski-Wende, Karen L Margolis

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 4 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Insulin Resistance: The Increased Risk of Cancers.Current oncology (Toronto, Ont.) · 2024
    Review
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  8. Article
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  16. Article
  17. Increased Risk of Site-Specific Cancer in People with Type 2 Diabetes: A National Cohort Study.International journal of environmental research and public health · 2019
    Article
  18. Thyroid Dysfunction and Type 2 Diabetes Mellitus: Screening Strategies and Implications for Management.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2019
    Review
  19. Article
  20. Association Between Metformin and Sulfonylurea Monotherapies and Cancer Incidence: A Real-World Cohort Study in Shanghai, China.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

Juhua LuoDepartment of Epidemiology and Biostatistics (J.L.), School of Public Health, Indiana University, Bloomington, Indiana 47405; Division of Endocrinology (L.P.), Emory University, Atlanta, Georgia 30322; School of Public Health (S.L.), The Warren Alpert School of Medicine, Brown University, Providence, Rhode Island 02912; Department of Social and Preventive Medicine (J.W.-W.), University at Buffalo, Buffalo, New York 14214; and HealthPartners Institute for Education and Research (K.L.M.), Minneapolis, Minnesota 55440.
Lawrence PhillipsDepartment of Epidemiology and Biostatistics (J.L.), School of Public Health, Indiana University, Bloomington, Indiana 47405; Division of Endocrinology (L.P.), Emory University, Atlanta, Georgia 30322; School of Public Health (S.L.), The Warren Alpert School of Medicine, Brown University, Providence, Rhode Island 02912; Department of Social and Preventive Medicine (J.W.-W.), University at Buffalo, Buffalo, New York 14214; and HealthPartners Institute for Education and Research (K.L.M.), Minneapolis, Minnesota 55440.
Simin LiuDepartment of Epidemiology and Biostatistics (J.L.), School of Public Health, Indiana University, Bloomington, Indiana 47405; Division of Endocrinology (L.P.), Emory University, Atlanta, Georgia 30322; School of Public Health (S.L.), The Warren Alpert School of Medicine, Brown University, Providence, Rhode Island 02912; Department of Social and Preventive Medicine (J.W.-W.), University at Buffalo, Buffalo, New York 14214; and HealthPartners Institute for Education and Research (K.L.M.), Minneapolis, Minnesota 55440.
Jean Wactawski-WendeDepartment of Epidemiology and Biostatistics (J.L.), School of Public Health, Indiana University, Bloomington, Indiana 47405; Division of Endocrinology (L.P.), Emory University, Atlanta, Georgia 30322; School of Public Health (S.L.), The Warren Alpert School of Medicine, Brown University, Providence, Rhode Island 02912; Department of Social and Preventive Medicine (J.W.-W.), University at Buffalo, Buffalo, New York 14214; and HealthPartners Institute for Education and Research (K.L.M.), Minneapolis, Minnesota 55440.
Karen L MargolisDepartment of Epidemiology and Biostatistics (J.L.), School of Public Health, Indiana University, Bloomington, Indiana 47405; Division of Endocrinology (L.P.), Emory University, Atlanta, Georgia 30322; School of Public Health (S.L.), The Warren Alpert School of Medicine, Brown University, Providence, Rhode Island 02912; Department of Social and Preventive Medicine (J.W.-W.), University at Buffalo, Buffalo, New York 14214; and HealthPartners Institute for Education and Research (K.L.M.), Minneapolis, Minnesota 55440.
Brown University · USEmory University · USHealthPartners · USIndiana University Bloomington · USUniversity at Buffalo, State University of New York · US

Funding

Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
NCATS NIH HHS UL1 TR001108NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CWHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

objectiveThe objective of this study was to assess the relationships among diabetes, diabetes treatment and thyroid cancer risk using a large prospective cohort, the Women's Health Initiative.

methodsA total of 147 934 women who were free of known cancer at baseline were followed prospectively. Diabetes status and diabetes treatment at baseline and during follow-up were ascertained. Incident cases of thyroid cancers were confirmed by physician review of central medical records and pathology reports. Time-dependent Cox proportional hazards regressions were used to estimate hazard ratios and 95% confidence intervals for thyroid cancer risk associated with diabetes status, diabetes treatment, and duration of diabetes.

resultsWith a median follow-up time of 15.9 years, 391 incident thyroid cancers were identified. We found no significant associations between thyroid cancer and diabetes (hazard ratio = 1.09; 95% confidence interval, 0.79-1.52), diabetes treatment, or duration of diabetes.

conclusionOur findings do not support the hypothesis that diabetes, or treatment of diabetes is associated with risk of thyroid cancer among postmenopausal women. Studies to investigate the specific effects of hyperinsulinemia and insulin resistance on thyroid cancer risk may provide additional information.

Indexed as

AgedDiabetes ComplicationsDiabetes MellitusFemaleFollow-Up StudiesHumansHypoglycemic AgentsMiddle AgedRisk FactorsThyroid NeoplasmsUnited StatesWomen's HealthHypoglycemic Agents

Identifiers

PMID26760177
PMCPMC4803153
OpenAlexW2234592829

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.