ArticleEnvironmental science & technology2016
Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework.
Article in Environmental science & technology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Organizing mechanism-related information on chemical interactions using a framework based on the aggregate exposure and adverse outcome pathways.Environment international · 2020Pooled it
- From Food Additives and Contaminants to the Human Exposome: A Precision Toxicology Framework for Next-Generation Food Safety.Foods (Basel, Switzerland) · 2026Article
- The Role of ES&T in Advancing Environmental Toxicology and Chemical Risk Assessment: Past, Present, and Future.Environmental science & technology · 2026Review
- How can academic researchers more effectively contribute to environmental toxicology and health efforts for regulatory decisions, policymakers, nonprofits, and communities?Journal of toxicology and environmental health. Part B, Critical reviews · 2026Review
- Review of human health exposure assessment frameworks in the United States and development of a unified framework for exposure assessment practitioners.Frontiers in public health · 2026Review
- ExpoPath: A method for identifying and annotating exposure pathways from chemical co-occurrence networks.The Science of the total environment · 2025Article
- The GeoTox Package: open-source software for connecting spatiotemporal exposure to individual and population-level risk.Human genomics · 2025Article
- Comprehensive computational analysis via Adverse Outcome Pathways and Aggregate Exposure Pathways in exploring synergistic effects from radon and tobacco smoke on lung cancer.Frontiers in public health · 2025Article
- The GeoTox Package: Open-source software for connecting spatiotemporal exposure to individual and population-level risk.medRxiv : the preprint server for health sciences · 2024Article
- Gene-environment interactions within a precision environmental health framework.Cell genomics · 2024Review
- Exploring applications of non-targeted analysis in the characterization of the prenatal exposome.The Science of the total environment · 2024Article
- Transforming environmental health datasets from the comparative toxicogenomics database into chord diagrams to visualize molecular mechanisms.Frontiers in toxicology · 2024Article
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- Article
- A geospatial modeling approach to quantifying the risk of exposure to environmental chemical mixtures via a common molecular target.The Science of the total environment · 2023Article
- Review
- An integrative systems biology strategy to support the development of adverse outcome pathways (AOPs): a case study on radiation-induced microcephaly.Frontiers in cell and developmental biology · 2023Article
- Article
- Enhancing the use of exposure science across EU chemical policies as part of the European Exposure Science Strategy 2020-2030.Journal of exposure science & environmental epidemiology · 2022Article
- Defining a new perspective in Environmental Health: the healing environment.International journal of biometeorology · 2022Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Driven by major scientific advances in analytical methods, biomonitoring, computation, and a newly articulated vision for a greater impact in public health, the field of exposure science is undergoing a rapid transition from a field of observation to a field of prediction. Deployment of an organizational and predictive framework for exposure science analogous to the "systems approaches" used in the biological sciences is a necessary step in this evolution. Here we propose the aggregate exposure pathway (AEP) concept as the natural and complementary companion in the exposure sciences to the adverse outcome pathway (AOP) concept in the toxicological sciences. Aggregate exposure pathways offer an intuitive framework to organize exposure data within individual units of prediction common to the field, setting the stage for exposure forecasting. Looking farther ahead, we envision direct linkages between aggregate exposure pathways and adverse outcome pathways, completing the source to outcome continuum for more meaningful integration of exposure assessment and hazard identification. Together, the two frameworks form and inform a decision-making framework with the flexibility for risk-based, hazard-based, or exposure-based decision making.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.