ArticleCanadian family physician Medecin de famille canadien2015
Acute rheumatic fever in First Nations communities in northwestern Ontario: Social determinants of health "bite the heart".
Article in Canadian family physician Medecin de famille canadien, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Clinical Presentation and Management of Patients Referred for Transthoracic Echocardiography in Canada's Arctic Region.CJC open · 2026Article
- Epidemiology and determinants of cardiovascular disease in Indigenous populations.Nature reviews. Cardiology · 2026Review
- Global disparities in the detection and management of rheumatic heart disease in pregnancy across endemic settings.Frontiers in surgery · 2026Review
- Article
- Acute rheumatic fever presenting as fulminant myocarditis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2024Article
- Risk Factors of Rheumatic Heart Disease in a Children's Hospital in Khartoum: A Case-Control Study.Cureus · 2024Article
- Learning From Our Strengths: Exploring Strategies to Support Heart Health in Indigenous Communities.CJC open · 2024Review
- Acute pharyngitis in children and adults: descriptive comparison of current recommendations from national and international guidelines and future perspectives.European journal of pediatrics · 2023Review
- Heart Health Begins With Community: Community-Based Research Exploring Innovative Strategies to Support First Nations Heart Health.CJC open · 2023Article
- Review
- Incidence of poststreptococcal glomerulonephritis in northwestern Ontario: Cross-sectional study at a tertiary care centre.Canadian family physician Medecin de famille canadien · 2022Article
- Rheumatic Heart Disease in the United States: Forgotten But Not Gone: Results of a 10 Year Multicenter Review.Journal of the American Heart Association · 2021Article
- The development of a community-based public health response to an outbreak of post-streptococcal glomerulonephritis in a First Nations community.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2021Article
- Rheumatic Heart Disease in Pregnancy: New Strategies for an Old Disease?Global heart · 2021Review
- Contemporary Incidence and Prevalence of Rheumatic Fever and Rheumatic Heart Disease in Australia Using Linked Data: The Case for Policy Change.Journal of the American Heart Association · 2020Article
- Streptococcus: An organism causing diseases beyond neglect.PLoS neglected tropical diseases · 2020Article
- Antibiotic use among twelve Canadian First Nations communities: a retrospective chart review of skin and soft tissue infections.BMC infectious diseases · 2020Article
- Acute Rheumatic Fever: A Disease of the Past?Case reports in infectious diseases · 2020Article
- Acute Rheumatic Fever and Kawasaki Disease Occurring in a Single Patient.Frontiers in pediatrics · 2020Article
- Rheumatic heart disease: infectious disease origin, chronic care approach.BMC health services research · 2017Review
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Authors and funding
11 authors at 8 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo document a case series of 8 young First Nations patients diagnosed with acute rheumatic fever (ARF), a preventable disease that resulted in the death of 2 patients, in northwestern Ontario in the context of late diagnosis, overcrowded housing, and inadequate public health response.
designRetrospective case series over an 18-month period.
settingRemote First Nations communities in northwestern Ontario.
participantsEight patients with ARF.
main outcome measuresIncidence, mortality, residual rheumatic heart disease, time to diagnosis, barriers to diagnosis and treatment, housing situation of patients, patient demographic characteristics (age, sex), and investigation results.
resultsThe incidence of ARF in this population was 21.3 per 100,000, which is 75 times greater than the overall Canadian estimated incidence. The average patient age was 9.4 years. Most cases developed joint findings, and 5 of the surviving patients had rheumatic heart disease when they received echocardiography. The average time to diagnosis was 88 days. Two 4-year-old children died from ARF. Most patients lived in inadequate and crowded housing.
conclusionThis rare disease still exists in remote First Nations communities. These communities demonstrate an incidence equal to that in aboriginal communities in Australia and New Zealand, which have among the highest international incidence of ARF. Primordial prevention, including improved on-reserve housing, is urgently needed. Case detection and ongoing surveillance for primary and secondary prophylaxis requires a well resourced regional strategy.
Indexed as
Identifiers
26759842PMC4607335W2209003029What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.