Evidence map›Paper›PMID 26759722›Full record

ReviewMilitary Medical Research2016

Indirect traumatic optic neuropathy.

Eric L Singman, Nitin Daphalapurkar, Helen White, Thao D Nguyen, Lijo Panghat, Jessica Chang, Timothy McCulley

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Military Medical Research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Traumatic optic neuropathy treatment trial (TONTT): open label, phase 3, multicenter, semi-experimental trial.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eric L SingmanWilmer Eye Institute at Johns Hopkins Hospital, Baltimore, Maryland USA.
Nitin DaphalapurkarWhiting School of Engineering, Johns Hopkins University, Baltimore, MD USA.
Helen WhiteDirector of Informatics and Information Management, Vision Center of Excellence [VCE], Office of the Assistant Secretary of Defense for Health Affairs [ASD-HA], United States Department of Defense [DOD], Walter Reed National Military Medical Center, Bethesda, MD USA.
Thao D NguyenWhiting School of Engineering, Johns Hopkins University, Baltimore, MD USA.
Lijo PanghatWhiting School of Engineering, Johns Hopkins University, Baltimore, MD USA.
Jessica ChangWilmer Eye Institute at Johns Hopkins Hospital, Baltimore, Maryland USA.
Timothy McCulleyWilmer Eye Institute at Johns Hopkins Hospital, Baltimore, Maryland USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Indirect traumatic optic neuropathy (ITON) refers to optic nerve injury resulting from impact remote to the optic nerve. The mechanism of injury is not understood, and there are no confirmed protocols for prevention, mitigation or treatment. Most data concerning this condition comes from case series of civilian patients suffering blunt injury, such as from sports- or motor vehicle-related concussion, rather than military-related ballistic or blast damage. Research in this field will likely require the development of robust databases to identify patients with ITON and follow related outcomes, in addition to both in-vivo animal and virtual human models to study the mechanisms of damage and potential therapies.

Indexed as

BiomechanicsBlastBluntIndirect traumaNeuropathyOptic nerveVirtual model

Identifiers

PMID26759722
PMCPMC4709956

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.