ArticleBiology of sex differences2016
Spatial sexual dimorphism of X and Y homolog gene expression in the human central nervous system during early male development.
Article in Biology of sex differences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Transcriptomic sex differences in early human fetal brain development.Communications biology · 2025Article
- Evolutionary divergence between homologous X-Y chromosome genes shapes sex-biased biology.Nature ecology & evolution · 2025Article
- Cellular sex throughout the organism underlies somatic sexual differentiation.Nature communications · 2024Article
- Temporal sex specific brain gene expression pattern during early rat embryonic development.Frontiers in cell and developmental biology · 2024Article
- Sex differences in early and term placenta are conserved in adult tissues.Biology of sex differences · 2022Article
- Y chromosome is moving out of sex determination shadow.Cell & bioscience · 2022Review
- Sex Differences in the Human Brain Transcriptome of Cases With Schizophrenia.Biological psychiatry · 2022Article
- Deletions on Chromosome Y and Downregulation of theCancers · 2021Article
- X-chromosome regulation and sex differences in brain anatomy.Neuroscience and biobehavioral reviews · 2021Review
- Quantitative analysis of Y-Chromosome gene expression across 36 human tissues.Genome research · 2020Article
- Genes that escape from X-chromosome inactivation: Potential contributors to Klinefelter syndrome.American journal of medical genetics. Part C, Seminars in medical genetics · 2020Review
- Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents.Molecular biology and evolution · 2020Article
- Article
- Novel Y-Chromosome Long Non-Coding RNAs Expressed in Human Male CNS During Early Development.Frontiers in genetics · 2019Article
- Genetics of the human Y chromosome and its association with male infertility.Reproductive biology and endocrinology : RB&E · 2018Review
- Stage 1 Registered Report: Variation in neurodevelopmental outcomes in children with sex chromosome trisomies: protocol for a test of the double hit hypothesis.Wellcome open research · 2018Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRenewed attention has been directed to the functions of the Y chromosome in the central nervous system during early human male development, due to the recent proposed involvement in neurodevelopmental diseases. PCDH11Y and NLGN4Y are of special interest because they belong to gene families involved in cell fate determination and formation of dendrites and axon.
methodsWe used RNA sequencing, immunocytochemistry and a padlock probing and rolling circle amplification strategy, to distinguish the expression of X and Y homologs in situ in the human brain for the first time. To minimize influence of androgens on the sex differences in the brain, we focused our investigation to human embryos at 8-11 weeks post-gestation.
resultsWe found that the X- and Y-encoded genes are expressed in specific and heterogeneous cellular sub-populations of both glial and neuronal origins. More importantly, we found differential distribution patterns of X and Y homologs in the male developing central nervous system.
conclusionsThis study has visualized the spatial distribution of PCDH11X/Y and NLGN4X/Y in human developing nervous tissue. The observed spatial distribution patterns suggest the existence of an additional layer of complexity in the development of the male CNS.
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