Evidence map›Paper›PMID 26759600›Full record

ReviewEmerging themes in epidemiology2016

The obese gut microbiome across the epidemiologic transition.

Lara R Dugas, Miles Fuller, Jack Gilbert, Brian T Layden

Abstract readReview
In one paragraph

Review in Emerging themes in epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The association between body mass index and the oral Firmicutes and Bacteroidetes profiles of healthy individuals.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
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  15. Observational
  16. Characteristics of Gut Microbiota in Cerulein-Induced Chronic Pancreatitis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lara R DugasPublic Health Sciences, Stritch School of Medicine, Loyola University Chicago, 2160 S. 1st Ave, Maywood, IL 60153 USA.
Miles FullerDivision of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Evanston, USA.
Jack GilbertArgonne National Laboratory, Biosciences Department, Institute for Genomic and Systems Biology, 9700 South Cass Avenue, Argonne, IL 60439 USA ; Department of Ecology and Evolution, University of Chicago, 1101 E 57th Street, Chicago, IL 60637 USA ; Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA 02543 USA ; College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058 China.
Brian T LaydenDivision of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Evanston, USA ; Jesse Brown Veterans Affairs Medical Center, Chicago, IL USA.

Funding

Mentoring For Success: Developing Fundamental Skills For Biomedical ResearchR25GM079300 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MCGEE, RICHARD · 2007 to 2020
$6.6M
Role of Short Chain Fatty Acids and their Receptors in Islet FunctionIK2BX001587 · VA · JESSE BROWN VA MEDICAL CENTER · PI LAYDEN, BRIAN THOMAS · 2012 to 2016
–
BLRD VA IK2 BX001587NIGMS NIH HHS R25 GM079300
6 · The paper itself

Abstract

The obesity epidemic has emerged over the past few decades and is thought to be a result of both genetic and environmental factors. A newly identified factor, the gut microbiota, which is a bacterial ecosystem residing within the gastrointestinal tract of humans, has now been implicated in the obesity epidemic. Importantly, this bacterial community is impacted by external environmental factors through a variety of undefined mechanisms. We focus this review on how the external environment may impact the gut microbiota by considering, the host's geographic location 'human geography', and behavioral factors (diet and physical activity). Moreover, we explore the relationship between the gut microbiota and obesity with these external factors. And finally, we highlight here how an epidemiologic model can be utilized to elucidate causal relationships between the gut microbiota and external environment independently and collectively, and how this will help further define this important new factor in the obesity epidemic.

Indexed as

Geographical differencesGut microbiomeObesity

Identifiers

PMID26759600
PMCPMC4710045

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.