ArticlePostepy dermatologii i alergologii2015
Polymorphisms in the cytochrome P-450 (CYP) 1A1 and 17 genes are not associated with acne vulgaris in the Polish population.
Article in Postepy dermatologii i alergologii, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed, 9 citations in OpenAlex.
- The possible role of diet in the pathogenesis of adult female acne.Postepy dermatologii i alergologii · 2016Review
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7 authors at 1 institution in 1 country.
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Abstract
introductionThe pathogenesis of acne is complex, multifactorial and not well understood. The genetic background of this dermatosis is well documented.
aimTo assess the frequency of -34 T > C single nucleotide polymorphism in the promoter of the CYP17 gene as well as m1 (+6,235 T > C) and m2 (+4,889 A > G) mutation in the coding region CYP1A1 gene acne patients from the Northern Polish population. MATERIAL AND
methodsThe study included 115 acne patients and 94 healthy controls (aged over 20) without acne in anamnesis. The CYP1A1 polymorphism was analyzed by polymerase chain reaction (PCR). The restriction fragment length polymorphism (RFLP) was used to analyze m1 mutation and allele-specific PCR in the case of m2 mutation. The CYP17 polymorphism was analyzed by RFLP. The results were evaluated by the Pearson's χ(2) test.
resultsThere were no statistically significant associations between allele and genotype frequencies between the acne and the control group.
conclusionsWe did not confirm the role of the CYP1A1 and CYP17 gene as predictor factors for acne development in the Polish population.
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