ReviewNigerian medical journal : journal of the Nigeria Medical Association
Reasons why West Africa continues to be a hotbed for hepatocellular carcinoma.
Review in Nigerian medical journal : journal of the Nigeria Medical Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- West African Medicinal Plant Substances and Molecules Activities Against Viral Hepatitis B and Hepatocellular Carcinoma.Recent patents on anti-cancer drug discovery · 2026Review
- Care-seeking among hepatocellular carcinoma patients in Uganda: health system navigation and its impact on diagnosis and survival in a prospective case-cohort study.BMJ public health · 2026Article
- Global, regional, and national burden of gastrointestinal cancers in early onset and young women, 1990-2021: analysis of data from the Global Burden of Disease study 2021.Journal of gastrointestinal oncology · 2025Article
- Predictors of health-seeking behavior in patients with chronic liver disease and a comparison of health-seeking based on patient-type.BMC gastroenterology · 2025Article
- Mental health and quality of life in patients with chronic liver disease: a single-center structural equation model.BMC gastroenterology · 2024Article
- The impact of HIV infection on clinical presentation and mortality among persons with hepatocellular carcinoma in Kampala, Uganda.BMC infectious diseases · 2023Article
- Hepatocellular carcinoma presentation and prognosis among Nigerian adults with and without HIV.PloS one · 2023Observational
- Hepatocellular Carcinoma in Sub-Saharan Africa.JCO global oncology · 2021Article
- Cancer in Africa: Is It a Genetic or Environmental Health Problem?Frontiers in oncology · 2020Review
- Hepatocellular carcinoma in Ghana: a retrospective analysis of a tertiary hospital data.The Pan African medical journal · 2020Article
- Disease Burden of Hepatocellular Carcinoma: A Global Perspective.Digestive diseases and sciences · 2019Review
- Review
- Hepatitis B virus sequencing and liver fibrosis evaluation in HIV/HBV co-infected Nigerians.Tropical medicine & international health : TM & IH · 2017Article
- Cancers Attributable to Alcohol Consumption in Nigeria: 2012-2014.Frontiers in oncology · 2017Article
- Engaging One Health for Non-Communicable Diseases in Africa: Perspective for Mycotoxins.Frontiers in public health · 2017Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocellular carcinoma (HCC) exhibits a huge disease burden on West Africa, with a large proportion of all HCC cases worldwide occurring in the sub-region. The high HCC prevalence is due to the endemicity of a number of risk factors, most notably hepatitis B, C and HIV. West African HCC also displays a poor prognosis. Generally speaking, this is owing to more aggressive tumours, late patient presentation and inadequate management. Exposure to chronic viral hepatitis, more carcinogenic West African strains of hepatitis B virus and carcinogens such as aflatoxin B1 all encourage tumour growth. Lack of patient confidence in the healthcare system contributes to poor health-seeking behaviors and management of the disease can be lacking, due in part to poor health infrastructure, resources available and lack of access to expensive treatment. There is also much we do not know about West African HCC, especially the effect rising obesity and alcohol use may have on this disease in the future. Suggestions for improvement are discussed, including surveillance of high-risk groups. Although there is much to be done before West African HCC is thought to be a curable disease, many steps have been taken to move in the right direction.
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