Evidence map›Paper›PMID 26759497›Full record

ArticleJournal of the Pediatric Infectious Diseases Society2017

Shedding of Oral Poliovirus Vaccine (OPV) by HIV-Infected and -Uninfected Mothers of OPV-Vaccinated Zimbabwean Infants.

Marisa Holubar, Stephanie B Troy, Kusum Nathoo, Lynda Stranix-Chibanda, Georgina Musingwini, Nivedita Srinivas, ChunHong Huang, Alexandra Junn, Meira S Halpern, Yvonne A Maldonado

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Journal of the Pediatric Infectious Diseases Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Spatial Analyses of Oral Polio Vaccine Transmission in an Community Vaccinated With Inactivated Polio Vaccine.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018
    Trial
  2. Characterization of Household and Community Shedding and Transmission of Oral Polio Vaccine in Mexican Communities With Varying Vaccination Coverage.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018
    Trial
  3. Article
  4. Review
  5. Article
  6. Pediatric HIV Infection and Decreased Prevalence of OPV Point Mutations Linked to Vaccine-associated Paralytic Poliomyelitis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Marisa HolubarStanford University School of Medicine, California.
Stephanie B TroyEastern Virginia Medical School, Norfolk.
Kusum NathooUniversity of Zimbabwe College of Health Sciences.
Lynda Stranix-ChibandaUniversity of Zimbabwe College of Health Sciences.
Georgina MusingwiniZimbabwe AIDS Prevention Project-University of Zimbabwe Department of Community Medicine, Harare.
Nivedita SrinivasStanford University School of Medicine, California.
ChunHong HuangStanford University School of Medicine, California.
Alexandra JunnPrinceton University, New Jersey.
Meira S HalpernStanford University School of Medicine, California.
Yvonne A MaldonadoStanford University School of Medicine, California.
Stanford University · USUniversity of Zimbabwe · ZWEastern Virginia Medical School · USPrinceton University · US

Funding

Global Epidemiology of Infectious DiseasesT32AI052073 · NIAID · STANFORD UNIVERSITY · PI Angelle Desiree LaBeaud, Stephen Patrick Luby · 2003 to 2026
$4.2M
Vaccination Strategies after Elimination of PoliomyelitisR01AI068577 · NIAID · STANFORD UNIVERSITY · PI MALDONADO, YVONNE A. · 2007 to 2011
$2.4M
Stanford Center for Clinical and Translational Education and Research (SCCTER)KL2KL2RR025743 · NCRR · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2008 to 2011
$1.9M
NCRR NIH HHS KL2 RR025743NIAID NIH HHS R01 AI068577NIAID NIH HHS T32 AI052073
6 · The paper itself

Abstract

Community circulation of oral poliovirus vaccine (OPV) likely begins with household transmission. We analyzed stool collected from Zimbabwean mothers who were infected with human immunodeficiency virus (HIV) and those who were uninfected with HIV 1 to 24 weeks after infant oral poliovirus vaccination. Overall, only 5% of the mothers had detectable OPV (16 of 304) despite high infant shedding rates. OPV shedding was similar between HIV-infected mothers and those who were uninfected (11 [6.4%] of 171 vs 5 [3.8%] of 133, respectively) and between mothers of HIV-infected infants and those of uninfected infants (2 [3.5%] of 57 vs 9 [6.3%] of 144, respectively). Mothers of vaccinated infants are unlikely to shed OPV, even when they are infected with HIV.

Indexed as

Developing CountriesInfectious Disease Transmission, VerticalMothersPoliovirus Vaccine, OralVirus SheddingAdultAnti-HIV AgentsCesarean SectionDrug Therapy, CombinationFemaleFollow-Up StudiesHIV InfectionsHumansInfantMalePregnancyAnti-HIV AgentsPoliovirus Vaccine, Oralcontact shedding of OPVOPVOPV sheddingoral poliovirus vaccinepoliovirus transmission

Identifiers

PMID26759497
PMCPMC5907849
OpenAlexW2309518135

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.