ArticleJournal of lipid research2016
Dietary rescue of altered metabolism gene reveals unexpected Drosophila mating cues.
Article in Journal of lipid research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 0 citations in OpenAlex.
- Selection, counterselection, and conditional gene expression for genetic biocontrol of insects.Insect science · 2026Review
- Review
- Slc38a9 Deficiency Induces Apoptosis and Metabolic Dysregulation and Leads to Premature Death in Zebrafish.International journal of molecular sciences · 2022Article
- The Desaturase GeneInternational journal of molecular sciences · 2020Article
- Experimental Introgression To Evaluate the Impact of Sex Specific Traits onG3 (Bethesda, Md.) · 2019Article
- The Desaturase Gene Family is Crucially Required for Fatty Acid Metabolism and Survival of the Brown Planthopper,International journal of molecular sciences · 2019Article
- Yeast quality in juvenile diet affects Drosophila melanogaster adult life traits.Scientific reports · 2018Article
- Behavioural elements and sensory cues involved in sexual isolation betweenRoyal Society open science · 2018Article
- Article
- Free flight odor tracking in Drosophila: Effect of wing chemosensors, sex and pheromonal gene regulation.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To develop and reproduce, animals need long-chain MUFAs and PUFAs. Although some unsaturated FAs (UFAs) can be synthesized by the organism, others must be provided by the diet. The gene, desat1, involved in Drosophila melanogaster UFA metabolism, is necessary for both larval development and for adult sex pheromone communication. We first characterized desat1 expression in larval tissues. Then, we found that larvae in which desat1 expression was knocked down throughout development died during the larval stages when raised on standard food. By contrast pure MUFAs or PUFAs, but not saturated FAs, added to the larval diet rescued animals to adulthood with the best effect being obtained with oleic acid (C18:1). Male and female mating behavior and fertility were affected very differently by preimaginal UFA-rich diet. Adult diet also strongly influenced several aspects of reproduction: flies raised on a C18:1-rich diet showed increased mating performance compared with flies raised on standard adult diet. Therefore, both larval and adult desat1 expression control sex-specific mating signals. A similar nutrigenetics approach may be useful in other metabolic mutants to uncover cryptic effects otherwise masked by severe developmental defects.
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