Evidence map›Paper›PMID 26759339›Full record

ArticleClinical oral investigations2016

In-vitro activity of sodium-hypochlorite gel on bacteria associated with periodontitis.

Karolina Jurczyk, Sandor Nietzsche, Claudia Ender, Anton Sculean, Sigrun Eick

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Clinical oral investigations, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Karolina JurczykDepartment of Periodontology, Laboratory of Oral Microbiology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, CH-3010, Bern, Switzerland.
Sandor NietzscheCenter of Electron Microscopy, University Hospital Jena, Jena, Germany.
Claudia EnderCenter of Electron Microscopy, University Hospital Jena, Jena, Germany.
Anton SculeanDepartment of Periodontology, Laboratory of Oral Microbiology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, CH-3010, Bern, Switzerland.
Sigrun EickDepartment of Periodontology, Laboratory of Oral Microbiology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, CH-3010, Bern, Switzerland. sigrun.eick@zmk.unibe.ch.
University of Bern · CHJena University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of the present study was to assess the antimicrobial activity of a sodium hypochlorite formulation including its components against bacteria associated with periodontal disease. MATERIALS AND

methodsSodium hypochlorite formulation (NaOCl gel), its components sodium hypochlorite (NaOCl), and the activating vehicle were compared with 0.1 % chlorhexidine digluconate (CHX) solution. The antimicrobial activity was proven by determination of minimal inhibitory concentrations (MIC), minimal bactericidal concentrations, and killing assays. Furthermore, the influence on formation as well as on a 4-day-old 6-species biofilm was tested.

resultsExcept for one strain (Parvimonas micra ATCC 33270 in case of NaOCl gel), the MICs both of the CHX solution and NaOCl gel did not exceed 10 % of the formulations' concentration. In general, MICs of the NaOCl gel were equal as of the CHX solution against Gram-negatives but higher against Gram-positive bacteria. CHX but not NaOCl gel clearly inhibited biofilm formation; however, the activity of NaOCl gel was more remarkable on a 4-day-old biofilm. NaOCl killed bacteria in the biofilm and interfered with the matrix.

conclusionsThe NaOCl gel acts antimicrobial in particular against Gram-negative species associated with periodontitis. Moreover, its component NaOCl hypochlorite is able to alter biofilm matrices. CLINICAL RELEVANCE: The NaOCl gel may represent a potential alternative for adjunctive topical antimicrobial treatment in periodontitis.

Indexed as

Anti-Infective Agents, LocalBiofilmsChlorhexidineGelsIn Vitro TechniquesMicrobial Sensitivity TestsPeriodontal DiseasesSodium HypochloriteStem CellsAnti-Infective Agents, LocalChlorhexidinechlorhexidine gluconateGelsSodium HypochloriteBiofilmPeriodontal infectionSodium hypochlorite

Identifiers

PMID26759339
OpenAlexW2238646147

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.