Evidence map›Paper›PMID 26759323›Full record

ArticleInternational urology and nephrology2016

Prognostic value of Ki67 and p63 expressions in bladder cancer patients who underwent radical cystectomy.

Lujia Wang, Minwei Zhou, Chenchen Feng, Peng Gao, Guanxiong Ding, Zhongwen Zhou, Haowen Jiang, Zhong Wu, Qiang Ding

Abstract read
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In one paragraph

Article in International urology and nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Desmocollin-3 and Bladder Cancer.Diseases (Basel, Switzerland) · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Scoring Systems for Immunohistochemistry in Urothelial Carcinoma.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  8. Magnetic resonance imaging-based radiomics signature for preoperative prediction of Ki67 expression in bladder cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Cancers · 2019
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lujia WangDepartment of Urology, Huashan Hospital of Fudan University, 12 Middle Wulumuqi Rd, Shanghai, 200040, People's Republic of China.
Minwei ZhouDepartment of General Surgery, Huashan Hospital of Fudan University, 12 Middle Wulumuqi Rd, Shanghai, 200040, People's Republic of China.
Chenchen FengDepartment of Urology, Huashan Hospital of Fudan University, 12 Middle Wulumuqi Rd, Shanghai, 200040, People's Republic of China.
Peng GaoDepartment of Urology, Huashan Hospital of Fudan University, 12 Middle Wulumuqi Rd, Shanghai, 200040, People's Republic of China.
Guanxiong DingDepartment of Urology, Huashan Hospital of Fudan University, 12 Middle Wulumuqi Rd, Shanghai, 200040, People's Republic of China.
Zhongwen ZhouDepartment of Pathology, Huashan Hospital of Fudan University, 12 Middle Wulumuqi Rd, Shanghai, 200040, People's Republic of China.
Haowen JiangDepartment of Urology, Huashan Hospital of Fudan University, 12 Middle Wulumuqi Rd, Shanghai, 200040, People's Republic of China.
Zhong WuDepartment of Urology, Huashan Hospital of Fudan University, 12 Middle Wulumuqi Rd, Shanghai, 200040, People's Republic of China.
Qiang DingDepartment of Urology, Huashan Hospital of Fudan University, 12 Middle Wulumuqi Rd, Shanghai, 200040, People's Republic of China. qiangding63@126.com.
Huashan Hospital · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRadical cystectomy (RC) is the gold standard treatment for patients with high-risk non-muscle-invasive bladder cancer and muscle-invasive bladder cancer (MIBC) . However, despite aggressive treatment, mortality rates of patients are still high. Therefore, it is crucial to indentify some practical prognostic factors for cancer-specific survival in those patients to guide our therapeutic strategies. MATERIALS AND

methodsWe included 103 patients treated with RC for urothelial bladder cancer (UBC) between July 2007 and June 2014 in our institution and analyzed their clinicopathological parameters. The mean follow-up was 22 months (range 2-89 months).

resultsAdvanced tumor T stage, N stage, ABO blood type, a history of DM and positive p63 expression were independent factors for worse survival in all patients who underwent RC. Moreover, in female gender, high Ki67 expression was significant risk factor for cancer-specific survival (CSS) in MIBC patients.

conclusionOur study demonstrated that immunohistochemical expressions of Ki67 and p63 are potential prognostic factors for UBC patients who underwent RC.

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Transitional CellCystectomyFemaleFollow-Up StudiesHumansImmunohistochemistryKi-67 AntigenMaleMembrane ProteinsMiddle AgedNeoplasm InvasivenessNeoplasm StagingBiomarkers, TumorCKAP4 protein, humanKi-67 AntigenMembrane ProteinsBladder cancerKi67p63Radical cystectomy

Identifiers

PMID26759323
OpenAlexW2297952319

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.