ArticleJournal of molecular histology2016
FHL2 mediates tooth development and human dental pulp cell differentiation into odontoblasts, partially by interacting with Runx2.
Article in Journal of molecular histology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Effects of Nel-like molecule-1 and bone morphogenetic protein 2 combination on rat pulp repair.Journal of molecular histology · 2019Article
- Methylation of Cdkn1c may be involved in the regulation of tooth development through cell cycle inhibition.Journal of molecular histology · 2018Article
- Mouse embryonic fibroblast (MEF)/BMP4-conditioned medium enhanced multipotency of human dental pulp cells.Journal of molecular histology · 2018Article
- Changes of mitochondrial respiratory function during odontogenic differentiation of rat dental papilla cells.Journal of molecular histology · 2018Article
- Nanostructured Ti surfaces and retinoic acid/dexamethasone present a spatial framework for the maturation and amelogenesis of LS-8 cells.International journal of nanomedicine · 2018Article
- Differential expression of transforming growth factor-beta1, connective tissue growth factor, phosphorylated-SMAD2/3 and phosphorylated-ERK1/2 during mouse tooth development.Journal of molecular histology · 2017Article
- Expression and distribution of three transient receptor potential vanilloid(TRPV) channel proteins in human odontoblast-like cells.Journal of molecular histology · 2017Article
- Blockade of LGR4 inhibits proliferation and odonto/osteogenic differentiation of stem cells from apical papillae.Journal of molecular histology · 2017Article
- Inhibition of chondroitin sulfate glycosaminoglycans incorporation affected odontoblast differentiation in cultured embryonic mouse molars.Journal of molecular histology · 2017Article
- Elevated expression of importin 8 in inflamed human dental pulps.International journal of clinical and experimental pathology · 2017Article
- Facioscapulohumeral muscular dystrophy (FSHD) region gene 1 (FRG1) expression and possible function in mouse tooth germ development.Journal of molecular histology · 2016Article
- Odontoblastic inductive potential of epithelial cells derived from human deciduous dental pulp.Journal of molecular histology · 2016Article
- JAB1 accelerates odontogenic differentiation of dental pulp stem cells.Journal of molecular histology · 2016Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The differentiation of mesenchymal cells in tooth germ and dental pulp cells into odontoblasts is crucial for dentin formation, and the transcription factor runt-related transcription factor (Runx2) is necessary for odontoblast differentiation. Our previous study demonstrated that four and a half LIM domains 2 (FHL2) may play an important role in tooth development and human dental pulp cell differentiation. This study aimed to determine whether FHL2 mediated the mesenchymal cells in tooth development and human dental pulp cell differentiation into odontoblasts by interacting with Runx2. The expression patterns of FHL2 and Runx2 were examined at the early stages of mouse molar development using double immunofluorescence staining. Western blot analysis and co-immunoprecipitation (Co-IP) were conducted for the preliminary study of the relationship between FHL2 and Runx2 in human dental pulp cell differentiation into odontoblasts. Results of double immunofluorescence staining showed that FHL2 and Runx2 exhibited similar expression patterns at the early stages of tooth development. Western blot analysis indicated that the expression patterns of FHL2 and Runx2 were synchronized on day 7 of induction, whereas those on day 14 differed. Co-IP analysis revealed positive bands of protein complexes, revealing the interaction of FHL2 and Runx2 on days 0, 7 and 14 of induction. Our data suggested that FHL2 might interact with Runx2 to mediate mesenchymal cell differentiation at the early stages of tooth development and human dental pulp cell differentiation.
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