Evidence map›Paper›PMID 26759253›Full record

ArticleJournal of clinical immunology2016

Is Pulmonary non-Tuberculous Mycobacterial Disease Linked with a High Burden of Latent Cytomegalovirus?

Fathiah S Amran, Kyungchul Kim, Andrew Lim, Rachel Thomson, Silvia Lee, Grant Waterer, Patricia Price

Abstract readLetter
PubMed Publisher
In one paragraph

Article in Journal of clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fathiah S AmranSchool of Laboratory & Pathology Medicine, University of Western Australia, Nedlands, Australia.
Kyungchul KimSchool of Laboratory & Pathology Medicine, University of Western Australia, Nedlands, Australia.
Andrew LimSchool of Laboratory & Pathology Medicine, University of Western Australia, Nedlands, Australia.
Rachel ThomsonSchool of Medicine, University of Queensland, Brisbane, QLD, Australia.
Silvia LeeDepartment of Microbiology, Royal Perth Hospital, Perth, Australia.
Grant WatererSchool of Medicine & Pharmacology, University of Western Australia, Nedlands, Australia.
Patricia PriceSchool of Medicine & Pharmacology, University of Western Australia, Nedlands, Australia. patricia.price@curtin.edu.au.ORCID http://orcid.org/0000-0003-3078-4451

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytomegalovirus (CMV) establishes lifelong infections with episodes of active replication. We hypothesized that recurrent CMV replication in older individuals may suppress protective immune responses to non-tuberculous mycobacteria (NTM) and so potentiate pulmonary disease. Accordingly, levels of antibodies to three CMV antigen preparations were higher in NTM patients than in age-matched controls. This did not reflect broad-spectrum B cell activation as total immunoglobulin levels were not equivalently increased.

Indexed as

CoinfectionVirus LatencyAdultAgedAged, 80 and overAntibodies, ViralAntigens, ViralCase-Control StudiesCytomegalovirusCytomegalovirus InfectionsFemaleHumansMaleMiddle AgedMycobacterium Infections, NontuberculousPneumonia, BacterialAntibodies, ViralAntigens, ViralCytomegalovirusimmunosuppressionnon-tuberculous mycobacteria

Identifiers

PMID26759253

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.