ArticleRheumatology international2016
Systemic sclerosis and silica exposure: a rare association in a large Brazilian cohort.
Article in Rheumatology international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Systemic sclerosis associated with silicosis in an agricultural worker: A case of Erasmus syndrome.Radiology case reports · 2026Article
- Impact of male sex in clinical and laboratory features of systemic sclerosis.Advances in rheumatology (London, England) · 2026Article
- From Silicosis to Systemic Sclerosis: Erasmus Syndrome in a Young Galamseyer-Case Report.Case reports in dermatological medicine · 2026Article
- Article
- Erasmus syndrome: case description of a rare entity.Quantitative imaging in medicine and surgery · 2024Article
- Article
- Clinical characteristics of systemic sclerosis patients with occupational silicosis.Clinical rheumatology · 2024Article
- Erasmus Syndrome.Radiology. Cardiothoracic imaging · 2022Article
- Erasmus Syndrome: A Case Report and Literature Review.The American journal of case reports · 2022Review
- Three's Company: Coexistence of Silicosis, Scleroderma, and Sjogren Syndrome in a Single Patient.Case reports in rheumatology · 2022Article
- Association of antinuclear antibody seropositivity with inhaled environmental exposures in patients with interstitial lung disease.ERJ open research · 2021Article
- Article
- Is exposure to environmental factors associated with a characteristic clinical and laboratory profile in systemic sclerosis? A retrospective analysis.Rheumatology international · 2021Observational
- Interstitial lung disease in Systemic sclerosis: insights into pathogenesis and evolving therapies.Mediterranean journal of rheumatology · 2018Review
- Systemic Sclerosis in Males-Deciphering the Enigma of Erasmus Syndrome.Indian journal of dermatologyArticle
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study is to describe the characteristics of patients with Erasmus syndrome (ES) in a large SSc Brazilian cohort. Nine hundred and forty-seven SSc patients attended at the Scleroderma Outpatient Clinic at two academic medical centers in Brazil and classified as SSc according to the ACR/EULAR criteria were retrospectively studied. Information on demographics, clinical, and laboratory features was obtained by chart review. ES patients had their HLA class II characterized by PCR-SSO method as available. Among the 947 SSc patients studied, nine (0.9 %) had ES. These ES patients were predominantly male (78 %) and smokers (68 %) and presented diffuse SSc (67 %). Mean time of occupational exposure to silica was 13.7 years, with mean age at onset of 47 years. Previous history of tuberculosis was referred by 33 % of the ES patients. All the ES patients presented Raynaud's phenomenon, esophageal involvement, and interstitial lung disease (ILD). Antinuclear antibodies were present in all the ES patients, while anti-topoisomerase I was positive in 44 % and no patient had anticentromere antibody. Three different HLA-DQB alleles (0506, 0305, and 0303) were observed. Compared to non-ES cases, patients with ES were associated with male gender (p < 0.001), diffuse SSc (p < 0.05), ILD (p < 0.05), positive anti-topoisomerase I antibodies (p < 0.05), and death (p < 0.05). Multivariate analysis did not confirm that silicosis is an independent risk factor for SSc. To conclude, ES was rare in this large SSc cohort, although associated with a bad prognosis.
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