Evidence map›Paper›PMID 26759148›Full record

ArticleHead and neck pathology2016

Phosphaturic Mesenchymal Tumor Involving the Head and Neck: A Report of Five Cases with FGFR1 Fluorescence In Situ Hybridization Analysis.

Jason K Wasserman, Bibianna Purgina, Chi K Lai, Denis Gravel, Alyssa Mahaffey, Diana Bell, Simion I Chiosea

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Treatment Advances in Tumor-Induced Osteomalacia.Calcified tissue international · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Clinicopathologic and molecular features of six cases of phosphaturic mesenchymal tumor.Virchows Archiv : an international journal of pathology · 2021
    Article
  9. Tumor-Induced Osteomalacia.Calcified tissue international · 2021
    Review
  10. Review
  11. Article
  12. Review
  13. Article
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  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jason K WassermanDepartment of Pathology and Laboratory Medicine, The Ottawa Hospital - General Campus, Ottawa, ON, Canada.
Bibianna PurginaDepartment of Pathology and Laboratory Medicine, The Ottawa Hospital - General Campus, Ottawa, ON, Canada.
Chi K LaiDepartment of Pathology and Laboratory Medicine, The Ottawa Hospital - General Campus, Ottawa, ON, Canada.
Denis GravelDepartment of Pathology and Laboratory Medicine, The Ottawa Hospital - General Campus, Ottawa, ON, Canada.
Alyssa MahaffeyDepartment of Pathology, Presbyterian University Hospital, University of Pittsburgh Medical Center, PUH A610.3, 200 Lothrop Street, Pittsburgh, PA, 15213, USA.
Diana BellDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Simion I ChioseaDepartment of Pathology, Presbyterian University Hospital, University of Pittsburgh Medical Center, PUH A610.3, 200 Lothrop Street, Pittsburgh, PA, 15213, USA. chioseasi@upmc.edu.
Ottawa Hospital · CAUPMC Presbyterian · USThe University of Texas MD Anderson Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phosphaturic mesenchymal tumor (PMT) is a rare neoplasm; however, it is the most common cause of tumor-induced osteomalacia (TIO), a paraneoplastic syndrome characterized by renal phosphate wasting and hypophosphatemia. A subset of PMTs harbours an FGFR1 translocation although this alteration has not been demonstrated in PMT involving a head and neck site. We present a series of five PMTs involving the head and neck and demonstrate the diagnostic utility of fluorescence in situ hybridization (FISH) for detecting FGFR1 translocations. Patients' age and sex, tumor location, original diagnosis, the duration of symptoms, the presence of TIO, biochemical results, and medical management were reviewed. The median age at presentation was 45 (range, 24-58 years) and TIO was present in three cases. Four tumors involved soft tissue and one involved bone. Four out of the five tumors in our series were initially misdiagnosed. Three tumors were ultimately categorized as malignant PMT (two patients developed metastatic disease). FGFR1 translocation was present in two out of four cases and remained unknown in one case. In summary, we report on five cases of PMTs arising in the head and neck and confirm utility of FGFR1 FISH in the diagnosis of a subset of PMT.

Indexed as

AdultFemaleHead and Neck NeoplasmsHumansHypophosphatemiaIn Situ Hybridization, FluorescenceMaleMesenchymomaMiddle AgedNeoplasms, Connective TissueOsteomalaciaParaneoplastic SyndromesReceptor, Fibroblast Growth Factor, Type 1Translocation, GeneticYoung AdultFGFR1 protein, humanReceptor, Fibroblast Growth Factor, Type 1FGFR1Fluorescence in situ hybridizationPhosphaturic mesenchymal tumourTranslocationTumor-induced osteomalacia

Identifiers

PMID26759148
PMCPMC4972751
OpenAlexW2258121403

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.