ArticleScientific reports2016
DNA methylation is critical for tooth agenesis: implications for sporadic non-syndromic anodontia and hypodontia.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Association between tooth agenesis and cancer: a systematic review.Journal of applied oral science : revista FOB · 2021Pooled it
- The Mechanisms and Application Value of Postbiotics in Caries Prevention and Management.Oral health & preventive dentistry · 2024Review
- State of the Art in the Treatment of Congenital Agenesis With Implant-Supported Prosthesis: A Comprehensive Multidisciplinary Management.Case reports in dentistry · 2024Article
- The EDA/EDAR/NF-κB pathway in non-syndromic tooth agenesis: A genetic perspective.Frontiers in genetics · 2023Review
- Novel Candidate Genes for Non-Syndromic Tooth Agenesis Identified Using Targeted Next-Generation Sequencing.Journal of clinical medicine · 2022Article
- Novel MSX1 variants identified in families with nonsyndromic oligodontia.International journal of oral science · 2021Article
- Melatonin-induced suppression of DNA methylation promotes odontogenic differentiation in human dental pulp cells.Bioengineered · 2020Article
- SP1 regulates KLF4 via SP1 binding motif governed by DNA methylation during odontoblastic differentiation of human dental pulp cells.Journal of cellular biochemistry · 2019Article
- Prevalence of WNT10A gene mutations in non-syndromic oligodontia.Clinical oral investigations · 2019Article
- Variations inBDJ open · 2019Article
- Pamidronate decreases bilirubin-impaired cell death and improves dentinogenic dysfunction of stem cells from human deciduous teeth.Stem cell research & therapy · 2018Article
- Review
- Genetic Disorders of Dental Development: Tales from the Bony Crypt.Current osteoporosis reports · 2017Review
- Deciphering the Epigenetic Code in Embryonic and Dental Pulp Stem Cells.The Yale journal of biology and medicine · 2016Review
- A Rare Incidence of Nonsyndromic Mandibular Incisor Agenesis in a Three-generation Family: Case Report and Literature Review.International journal of clinical pediatric dentistryArticle
- Esthetic and Functional Rehabilitation of a Child with Complete Anodontia in Primary and Mixed Dentition Stage: A Case Report with 4-year Follow-up.International journal of clinical pediatric dentistryArticle
- Research algorithm for the detection of genetic patterns and phenotypic variety of non-syndromic dental agenesis.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieObservational
- Early functional, esthetic, and psychological rehabilitation of preschool child with nonsyndromic oligodontia and anodontia in mixed dentition stage through conservative systematic approach: A case report with 5-year follow-up.Contemporary clinical dentistryArticle
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypodontia is caused by interactions among genetic, epigenetic, and environmental factors during tooth development, but the actual mechanism is unknown. DNA methylation now appears to play a significant role in abnormal developments, flawed phenotypes, and acquired diseases. Methylated DNA immunoprecipitation (MeDIP) has been developed as a new method of scanning large-scale DNA-methylation profiles within particular regions or in the entire genome. Here, we performed a genome-wide scan of paired DNA samples obtained from 4 patients lacking two mandibular incisors and 4 healthy controls with normal dentition. We scanned another female with non-syndromic anodontia and her younger brother with the same gene mutations of the PAX9,MSX1,AXIN2 and EDA, but without developmental abnormalities in the dentition. Results showed significant differences in the methylation level of the whole genome between the hypodontia and the normal groups. Nine genes were spotted, some of which have not been associated with dental development; these genes were related mainly to the development of cartilage, bone, teeth, and neural transduction, which implied a potential gene cascade network in hypodontia at the methylation level. This pilot study reveals the critical role of DNA methylation in hypodontia and might provide insights into developmental biology and the pathobiology of acquired diseases.
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Registered trials
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