ArticleBMC musculoskeletal disorders2016
Incidence and prevalence of total joint replacements due to osteoarthritis in the elderly: risk factors and factors associated with late life prevalence in the AGES-Reykjavik Study.
Article in BMC musculoskeletal disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Effects of hyaluronic acid combined with anti-inflammatory drugs compared with hyaluronic acid alone, in clinical trials and experiments in osteoarthritis: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2017Pooled it
- Trial
- A virtual knee replacement (vKR) multi-component endpoint for knee osteoarthritis based on patient-reported PROs: Data from the Osteoarthritis Initiative.Osteoarthritis and cartilage · 2025Article
- Trends in Outpatient Primary Total Hip and Knee Replacement From the Hospital Outpatient Department and Ambulatory Surgery Center Settings in New York State.Arthroplasty today · 2025Article
- Does Combined Treatment with Tranexamic Acid and Vancomycin Affect Human Chondrocytes In Vitro?Pharmaceuticals (Basel, Switzerland) · 2024Article
- Impact of diabetes mellitus on osteoarthritis: a scoping review on biomarkers.Expert reviews in molecular medicine · 2024Article
- A single intraarticular injection of a tranexamic acid-modified hyaluronic acid (HA/TXA) alleviates pain and reduces OA development in a murine model of monosodium iodoacetate-induced osteoarthritis.Frontiers in pharmacology · 2024Article
- Two-stage revision for treatment of tuberculous prosthetic hip infection: an outcome analysis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2023Review
- Construction of an Administrative Osteoarthritis Severity Index.ACR open rheumatology · 2022Article
- The Impact of Psychological Health on Patient Recovery After Arthroplasty.Frontiers in psychiatry · 2022Article
- Human Bone Mesenchymal Stem Cell-Derived Exosomes Inhibit IL-1β-Induced Inflammation in Osteoarthritis Chondrocytes.Cell journal · 2021Article
- Diffuse idiopathic skeletal hyperostosis in elderly Icelanders and its association with the metabolic syndrome: the AGES-Reykjavik Study.Scandinavian journal of rheumatology · 2021Article
- Exosomes Isolated From Bone Marrow Mesenchymal Stem Cells Exert a Protective Effect on Osteoarthritis via lncRNA LYRM4-AS1-GRPR-miR-6515-5p.Frontiers in cell and developmental biology · 2021Article
- Prior unilateral total hip arthroplasty does not influence the outcome of ipsilateral total knee arthroplasty.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020Article
- EUROVISCO Recommendations for Optimizing the Clinical Results of Viscosupplementation in Osteoarthritis.Cartilage · 2020Article
- EUROVISCO Guidelines for the Design and Conduct of Clinical Trials Assessing the Disease-Modifying Effect of Knee Viscosupplementation.Cartilage · 2020Article
- Incidence of total hip and total knee replacements from the prospective epidemiologic risk factor study: considerations for event driven clinical trial design.BMC musculoskeletal disorders · 2019Article
- Feasibility of Ski Mountaineering for Patients Following a Total Knee Arthroplasty: A Descriptive Field Study.International journal of environmental research and public health · 2019Article
- Hand and knee osteoarthritis are associated with reduced diameters in retinal vessels: the AGES-Reykjavik study.Rheumatology international · 2019Article
- Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundTotal joint replacements (TJRs) should be considered as one of few definite endpoints in osteoarthritis research. We analyzed factors associated with late-life prevalence and risk factors for incidence of TJRs due to osteoarthritis in a population based cohort.
methodsAfter exclusion of inflammatory arthritis and fractures as causes of TJR, 5170 participants in the AGES-Reykjavik Study (mean age (SD) 76.4(6), 58% females) were included for osteoarthritis studies. Three thousand one hundred thirty-three of them had a follow-up visit 5 years later.
resultsThe prevalence of having at least one joint replacement operation due to OA was 13.6% and the yearly incidence was 1.4%/year during the five-year follow-up. Factors positively associated with late life prevalence of TJR included BMI, hand OA severity, female gender, finger length ratio and spine BMD. Risk factors for TJRs in the incidence group were symptoms at initial visit, prior TJR in the contralateral joint and BMI. Much stronger associations were seen for TKR than for THR with discriminatory analysis showing an AUC 0.71 for late life prevalence and 0.84 for the incidence.
conclusionsThis study illustrates the importance of the different information expressed by late life prevalence vs. incidence on the factors associated with severe osteoarthritis of the knee and hip. The observation that prior TJR is a risk factor for subsequent TJR in the contralateral joint has not been described previously. The high power predictions for TKR suggest that a predictive model may be feasible, particularly if it can be extended by the addition of further predictive variables, perhaps through genetic, biomarker or imaging data.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.