ArticleCurrent genetics2016
Aneuploidy as a mechanism of adaptation to telomerase insufficiency.
Article in Current genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- Review
- Molecular signatures of aneuploidy-driven adaptive evolution.Nature communications · 2020Article
- Defining Signatures of Arm-Wise Copy Number Change and Their Associated Drivers in Kidney Cancers.International journal of molecular sciences · 2019Article
- Review
- Co-Operation between Aneuploidy and Metabolic Changes in Driving Tumorigenesis.International journal of molecular sciences · 2019Review
- Molecular characterization ofLife science alliance · 2019Article
- Adaptation in replicative senescence: a risky business.Current genetics · 2019Review
- How long does telomerase extend telomeres? Regulation of telomerase release and telomere length homeostasis.Current genetics · 2018Review
- Chromosome ends as adaptive beginnings: the potential role of dysfunctional telomeres in subtelomeric evolvability.Current genetics · 2018Review
- Induction and relocalization of telomeric repeat-containing RNAs during diauxic shift in budding yeast.Current genetics · 2018Article
- Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Rnr1's role in telomere elongation cannot be replaced by Rnr3: a role beyond dNTPs?Current genetics · 2018Review
- The evolutionarily conserved factor Sus1/ENY2 plays a role in telomere length maintenance.Current genetics · 2018Article
- Mec1Current genetics · 2018Article
- Industrial Relevance of Chromosomal Copy Number Variation in Saccharomyces Yeasts.Applied and environmental microbiology · 2017Review
- Timeless protection of telomeres.Current genetics · 2016Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cells' survival is determined by their ability to adapt to constantly changing environment. Adaptation responses involve global changes in transcription, translation, and posttranslational modifications of proteins. In recent years, karyotype changes in adapting populations of single cell organisms have been reported in a number of studies. More recently, we have described aneuploidy as an adaptation mechanism used by populations of budding yeast Saccharomyces cerevisiae to survive telomerase insufficiency induced by elevated growth temperature. Genetic evidence suggests that telomerase insufficiency is caused by decreased levels of the telomerase catalytic subunit Est2. Here, we present experiments arguing that the underlying cause of this phenomenon may be within the telomerase RNA TLC1: changes in the expression of TLC1 as well as mutations in the TLC1 template region affect telomere length equilibrium and the temperature threshold for the induction of telomerase insufficiency. We discuss what lies at the root of telomerase insufficiency, how cell populations overcome it through aneuploidy and whether reversible aneuploidy could be an adaptation mechanism for a variety of environmental stresses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.