ArticleScientific reports2016
Analysis of a four generation family reveals the widespread sequence-dependent maintenance of allelic DNA methylation in somatic and germ cells.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Mechanisms of Epigenetic Inheritance in Post-Traumatic Stress Disorder.Life (Basel, Switzerland) · 2024Review
- A systematic scientometric review of paternal inheritance of acquired metabolic traits.BMC biology · 2023Review
- Temporal Dynamics of DNA Methylation Patterns in Response to Rearing Juvenile Steelhead (Genes · 2019Article
- Transgenerational epigenetic influences of paternal environmental exposures on brain function and predisposition to psychiatric disorders.Molecular psychiatry · 2019Review
- Linking inter-individual variability to endocrine disruptors: insights for epigenetic inheritance.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- The NCI-60 Methylome and Its Integration into CellMiner.Cancer research · 2017Article
- Non-genetic transgenerational transmission of bipolar disorder: targeting DNA methyltransferases.Molecular psychiatry · 2016Article
- DNA methylation: conducting the orchestra from exposure to phenotype?Clinical epigenetics · 2016Review
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Authors and funding
23 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Differential methylation of the homologous chromosomes, a well-known mechanism leading to genomic imprinting and X-chromosome inactivation, is widely reported at the non-imprinted regions on autosomes. To evaluate the transgenerational DNA methylation patterns in human, we analyzed the DNA methylomes of somatic and germ cells in a four-generation family. We found that allelic asymmetry of DNA methylation was pervasive at the non-imprinted loci and was likely regulated by cis-acting genetic variants. We also observed that the allelic methylation patterns for the vast majority of the cis-regulated loci were shared between the somatic and germ cells from the same individual. These results demonstrated the interaction between genetic and epigenetic variations and suggested the possibility of widespread sequence-dependent transmission of DNA methylation during spermatogenesis.
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