Evidence map›Paper›PMID 26758438›Full record

ArticleClinical rheumatology2016

Evaluation of the effects of different supplementation on oxidative status in patients with rheumatoid arthritis.

Dragan Vasiljevic, Mirjana Veselinovic, Maja Jovanovic, Nevena Jeremic, Aleksandra Arsic, Vesna Vucic, Aleksandra Lucic-Tomic, Sandra Zivanovic, Dragan Djuric, Vladimir Jakovljevic

Abstract read
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Article in Clinical rheumatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
5.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Article
  6. Dietary fruits and arthritis.Food & function · 2018
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Dragan VasiljevicDepartment of Hygiene, Institute for Public Health, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Mirjana VeselinovicDepartment of Rheumatology, Internal Clinic, Clinical Center Kragujevac, Kragujevac, Serbia.
Maja JovanovicDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Nevena JeremicDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Aleksandra ArsicCentre of Research Excellence in Nutrition and Metabolism, Institute of Medical Research, University of Belgrade, Belgrade, Serbia.
Vesna VucicCentre of Research Excellence in Nutrition and Metabolism, Institute of Medical Research, University of Belgrade, Belgrade, Serbia.
Aleksandra Lucic-TomicDepartment of Rheumatology, Internal Clinic, Clinical Center Kragujevac, Kragujevac, Serbia.
Sandra ZivanovicDepartment of Medical Sciences, Faculty for Tourism, University of Kragujevac, Vrnjacka Banja, Serbia.
Dragan DjuricInstitute of Medical Physiology "Richard Burian," Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Vladimir JakovljevicDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica, 34000, Kragujevac, Serbia. drvladakgbg@yahoo.com.
University of Kragujevac · RSCentre of Research Excellence in Nutrition and Metabolism · RSClinical Centre of Kragujevac · RSUniversity of Belgrade · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid arthritis is a chronic inflammatory disease. Reactive oxygen species have been considered as aggravating factors for autoimmune diseases. Fatty acids had been linked in reduction of various diseases by augment of their antioxidant potential and antiinflammatory mechanisms. The aim of this study was to assess the oxidative status in patients with rheumatoid arthritis who used concentrated fish oil only or concentrated fish oil in combination with evening primrose oil in a period of 3 months. Subjects were divided into three groups. The group I consists of patients who had been taking only their regular rheumatologic therapy; group II, patients who had been taking concentrated fish oil; and group III, patients who had been taking concentrated fish oil and evening primrose oil. Peripheral blood samples were used for all the assays. We assessed the following oxidative stress markers: index of lipid peroxidation (thiobarbituric acid-reactive substances (TBARS)), hydrogen peroxide (H2O2), superoxide anion radical (O2 (-)), nitric oxide (NO), superoxide dismutase activity (SOD), catalase activity (CAT), and glutathione levels (GSH) in erythrocytes. There were no statistically significant changes for any of the oxidative stress parameters in group I. In group II, levels of TBARS, NO2 (-), and GSH were increased, while levels of H2O2 decreased. Increased values of TBARS, NO2 (-), and SOD were found in group III. Our findings indicate that intakes of fish oil and evening primrose oil may be of importance in mitigation of inflammation, disease activity, and oxidative stress biomarkers, through increased activities of antioxidant enzymes.

Indexed as

AgedAntioxidantsArthritis, RheumatoidBiomarkersDietary SupplementsFemaleFish OilsHumansHydrogen PeroxideLipid PeroxidationMiddle AgedNitric OxideOenothera biennisOxidative StressPlant OilsPostmenopauseAntioxidantsBiomarkersFish OilsHydrogen PeroxideNitric OxidePlant OilsThiobarbituric Acid Reactive SubstancesFatty acidsOxidative stressRheumatoid arthritis

Identifiers

PMID26758438
OpenAlexW2236085244

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.