Evidence map›Paper›PMID 26758363›Full record

ArticleAnnals of medicine2016

Depression or anxiety and all-cause mortality in adults with atrial fibrillation--A cohort study in Swedish primary care.

Per Wändell, Axel C Carlsson, Danijela Gasevic, Lars Wahlström, Jan Sundquist, Kristina Sundquist

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Article in Annals of medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  8. P2X7 receptor inhibition prevents atrial fibrillation in rodent models of depression.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
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  16. Negative Affect and Risk of Atrial Fibrillation: MESA.Journal of the American Heart Association · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Per Wändella Division of Family Medicine, Department of Neurobiology , Care Sciences and Society (NVS), Karolinska Institutet , Huddinge , Sweden ;
Axel C Carlssona Division of Family Medicine, Department of Neurobiology , Care Sciences and Society (NVS), Karolinska Institutet , Huddinge , Sweden ;
Danijela Gasevicd Centre for Population Health Sciences, College of Medicine and Veterinary Medicine, University of Edinburgh , Edinburgh , UK ;
Lars Wahlströme Centre for Psychiatry Research, Karolinska Institutet , Stockholm , Sweden ;
Jan Sundquistf Center for Primary Health Care Research, Lund University , Malmö , Sweden ;
Kristina Sundquistf Center for Primary Health Care Research, Lund University , Malmö , Sweden ;

Funding

Neighborhoods and Coronary Disease: Exploring Mechanisms and Improving MethodsR01HL116381 · NHLBI · LUNDS UNIVERSITET · PI SUNDQUIST, KRISTINA · 2014 to 2017
$1.9M
NHLBI NIH HHS R01 HL116381NHLBI NIH HHS R01HL116381
6 · The paper itself

Abstract

objectiveOur aim was to study depression and anxiety in atrial fibrillation (AF) patients as risk factors for all-cause mortality in a primary care setting.

methodsThe study population included adults (n = 12 283) of 45 years and older diagnosed with AF in 75 primary care centres in Sweden. The association between depression or anxiety and all-cause mortality was explored using Cox regression analysis, with hazard ratios (HRs) and 95% confidence intervals (95% CIs). Analyses were conducted in men and women, adjusted for age, educational level, marital status, neighborhood socio-economic status (SES), change of neighborhood status and anxiety or depression, respectively, and cardiovascular co-morbidities. As a secondary analysis, background factors and their association with depression or anxiety were explored.

resultsThe risk of all-cause mortality was higher among men with depression compared to their counterparts without depression even after full adjustment (HR = 1.28, 95% CI 1.08-1.53). For anxiety among men and anxiety or depression among women with AF, no associations were found. Cerebrovascular disease was more common among depressed AF patients.

conclusionsIncreased awareness of the higher mortality among men with AF and subsequent depression is called for. We suggest a tight follow-up and treatment of both ailments in clinical practice.

Indexed as

AgedAged, 80 and overAnxietyAtrial FibrillationCause of DeathCohort StudiesComorbidityDepressionFemaleFollow-Up StudiesHumansMaleMiddle AgedPrimary Health CareSocioeconomic FactorsSwedenAnticoagulantsanxietyatrial fibrillationco-morbiditydepressionfollow-upgendermortality

Identifiers

PMID26758363
PMCPMC4790080

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.