ArticleScientific reports2016
Metabolic traits of an uncultured archaeal lineage--MSBL1--from brine pools of the Red Sea.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 70 citations in OpenAlex.
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- Metabolic redundancy and specialisation of novel sulfide-oxidizing Sulfurimonas and Sulfurovum along the brine-seawater interface of the Kebrit Deep.Environmental microbiome · 2025Article
- Wood-Ljungdahl pathway encoding anaerobes facilitate low-cost primary production in hypersaline sediments at Great Salt Lake, Utah.FEMS microbiology ecology · 2024Article
- Community ecology and functional potential of bacteria, archaea, eukarya and viruses in Guerrero Negro microbial mat.Scientific reports · 2024Article
- Anaerobic hexadecane degradation by a thermophilic Hadarchaeon from Guaymas Basin.The ISME journal · 2024Article
- Diverse Bathyarchaeotal Lineages Dominate Archaeal Communities in the Acidic Dajiuhu Peatland, Central China.Microbial ecology · 2023Article
- Ancestral archaea expanded the genetic code with pyrrolysine.The Journal of biological chemistry · 2022Article
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- Bioprospecting the microbiome of Red Sea Atlantis II brine pool for peptidases and biosynthetic genes with promising antibacterial activity.Microbial cell factories · 2022Article
- Unconventional genetic code systems in archaea.Frontiers in microbiology · 2022Review
- Progress and Challenges in Studying the Ecophysiology of Archaea.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Fine-scale metabolic discontinuity in a stratified prokaryote microbiome of a Red Sea deep halocline.The ISME journal · 2021Article
- Four families of folate-independent methionine synthases.PLoS genetics · 2021Article
- Ecological distribution and potential roles of Woesearchaeota in anaerobic biogeochemical cycling unveiled by genomic analysis.Computational and structural biotechnology journal · 2021Article
- Diversity, ecology and evolution of Archaea.Nature microbiology · 2020Review
- Expanding the type IIB DNA topoisomerase family: identification of new topoisomerase and topoisomerase-like proteins in mobile genetic elements.NAR genomics and bioinformatics · 2020Article
- Deep Hypersaline Anoxic Basins as Untapped Reservoir of Polyextremophilic Prokaryotes of Biotechnological Interest.Marine drugs · 2020Review
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- Crystal Structure and Active Site Engineering of a Halophilic γ-Carbonic Anhydrase.Frontiers in microbiology · 2020Article
- Hyperdiverse archaea near life limits at the polyextreme geothermal Dallol area.Nature ecology & evolution · 2019Article
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The candidate Division MSBL1 (Mediterranean Sea Brine Lakes 1) comprises a monophyletic group of uncultured archaea found in different hypersaline environments. Previous studies propose methanogenesis as the main metabolism. Here, we describe a metabolic reconstruction of MSBL1 based on 32 single-cell amplified genomes from Brine Pools of the Red Sea (Atlantis II, Discovery, Nereus, Erba and Kebrit). Phylogeny based on rRNA genes as well as conserved single copy genes delineates the group as a putative novel lineage of archaea. Our analysis shows that MSBL1 may ferment glucose via the Embden-Meyerhof-Parnas pathway. However, in the absence of organic carbon, carbon dioxide may be fixed via the ribulose bisphosphate carboxylase, Wood-Ljungdahl pathway or reductive TCA cycle. Therefore, based on the occurrence of genes for glycolysis, absence of the core genes found in genomes of all sequenced methanogens and the phylogenetic position, we hypothesize that the MSBL1 are not methanogens, but probably sugar-fermenting organisms capable of autotrophic growth. Such a mixotrophic lifestyle would confer survival advantage (or possibly provide a unique narrow niche) when glucose and other fermentable sugars are not available.
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