ArticleScientific reports2016
Sublethal Dosage of Imidacloprid Reduces the Microglomerular Density of Honey Bee Mushroom Bodies.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 143 citations in OpenAlex.
- Never underestimate honeybees: Their exceptionally diverse adaptive strategies.Journal of advanced research · 2026Review
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- Neurotranscriptomic profiling of deformed wing virus-infected honey bee foragers (Apis mellifera) with different cognitive abilities.Biology open · 2025Article
- Sub-lethal imidacloprid exposure leads to presynaptic and postsynaptic alterations.Research square · 2025Article
- Neonicotinoids and Varroa mites force the extending of longevity in a bee colony during overwintering to forget.Scientific reports · 2025Article
- Unravelling nicotinic receptor and ligand features underlying neonicotinoid knockdown actions on the malaria vector mosquitoOpen biology · 2024Article
- Article
- Exploring neonicotinoid effects onFrontiers in physiology · 2024Article
- Sulfoxaflor influences the biochemical and histological changes on honeybees (Apis mellifera L.).Ecotoxicology (London, England) · 2023Article
- Gene expression in bumble bee larvae differs qualitatively between high and low concentration imidacloprid exposure levels.Scientific reports · 2023Article
- Oral exposure to thiacloprid-based pesticide (Calypso SC480) causes physical poisoning symptoms and impairs the cognitive abilities of bumble bees.BMC ecology and evolution · 2023Article
- Chronic larval exposure to thiacloprid impairs honeybee antennal selectivity, learning and memory performances.Frontiers in physiology · 2023Article
- The flavonoid rutin protects the bumble bee Bombus impatiens against cognitive impairment by imidacloprid and fipronil.The Journal of experimental biology · 2022Article
- The Synergistic Effect of Thiamethoxam and Synapsin dsRNA Targets Neurotransmission to Induce Mortality inInternational journal of molecular sciences · 2022Article
- Sublethal Dose ofInsects · 2022Article
- Pesticide risk to managed bees during blueberry pollination is primarily driven by off-farm exposures.Scientific reports · 2022Article
- Exposure of Larvae to Sublethal Thiacloprid Delays Bee Development and Affects Transcriptional Responses of Newly Emerged Honey Bees.Frontiers in insect science · 2022Article
- Chronic Effects of Imidacloprid on Honey Bee Worker Development-Molecular Pathway Perspectives.International journal of molecular sciences · 2021Review
- Review
- Identification of long noncoding RNAs reveals the effects of dinotefuran on the brain in Apis mellifera (Hymenopptera: Apidae).BMC genomics · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dramatic loss of honey bees is a major concern worldwide. Previous studies have indicated that neonicotinoid insecticides cause behavioural abnormalities and have proven that exposure to sublethal doses of imidacloprid during the larval stage decreases the olfactory learning ability of adults. The present study shows the effect of sublethal doses of imidacloprid on the neural development of the honey bee brain by immunolabelling synaptic units in the calyces of mushroom bodies. We found that the density of the synaptic units in the region of the calyces, which are responsible for olfactory and visual functions, decreased after being exposed to a sublethal dose of imidacloprid. This not only links a decrease in olfactory learning ability to abnormal neural connectivity but also provides evidence that imidacloprid damages the development of the nervous system in regions responsible for both olfaction and vision during the larval stage of the honey bee.
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