ArticleScientific reports2016
Large molecular systems landscape uncovers T cell trapping in human skin cancer.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- The immune landscape of melanoma microenvironmental crosstalk.Frontiers in immunology · 2026Review
- Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applications.Bone research · 2024Review
- Large-scale, three-dimensional tissue cytometry of the human kidney: a complete and accessible pipeline.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- Highly multiplexed immunofluorescence images and single-cell data of immune markers in tonsil and lung cancer.Scientific data · 2019Article
- Qualifying antibodies for image-based immune profiling and multiplexed tissue imaging.Nature protocols · 2019Article
- Muscle Satellite Cell Cross-Talk with a Vascular Niche Maintains Quiescence via VEGF and Notch Signaling.Cell stem cell · 2018Article
- A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers.Nature communications · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune surveillance of tumour cells is an important function of CD8 T lymphocytes, which has failed in cancer for reasons still unknown in many respect but mainly related to cellular processes in the tumour microenvironment. Applying imaging cycler microscopy to analyse the immune contexture in a human skin cancer we could identify and map 7,000 distinct cell surface-associated multi-protein assemblies. The resulting combinatorial geometry-based high-functional resolution led to discovery of a mechanism of T cell trapping in the epidermis, which involves SPIKE, a network of suprabasal keratinocyte projections piercing and interconnecting CD8 T cells. It appears initiated by clusters of infrabasal T and dendritic cells connected via cell projections across a fractured basal lamina to suprabasal keratinocytes and T lymphocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.