ArticlePhysiological genomics2016
Association of ACTN3 R577X but not ACE I/D gene variants with elite rugby union player status and playing position.
Article in Physiological genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Prediction of success in sports based on assumed individual genetic predisposition: lack of association with the C > T variant in the ACTN3 gene.Journal of physiological anthropology · 2025Pooled it
- Does theGenes · 2026Article
- Genetic Determinants of Endurance: A Narrative Review on Elite Athlete Status and Performance.International journal of molecular sciences · 2024Review
- Epigenetic Analysis of the Dopamine Transporter GeneInternational journal of molecular sciences · 2023Article
- Association betweenFrontiers in genetics · 2023Article
- Athletic performance, sports experience, and exercise addiction: an association study onFrontiers in psychology · 2023Article
- The association ofBiology of sport · 2022Article
- The Relationship betweenGenes · 2022Article
- Article
- The ACE and ACTN3 polymorphisms in female soccer athletes.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021Article
- Association of Genetic Variances inSports (Basel, Switzerland) · 2021Article
- Review
- No association between ACTN3 R577X and ACE I/D polymorphisms and endurance running times in 698 Caucasian athletes.BMC genomics · 2018Article
- COL5A1 gene variants previously associated with reduced soft tissue injury risk are associated with elite athlete status in rugby.BMC genomics · 2017Article
- GP73 regulates Hepatic Steatosis by enhancing SCAP-SREBPs interaction.Scientific reports · 2017Article
- Fat mass and obesity associated (FTO) gene influences skeletal muscle phenotypes in non-resistance trained males and elite rugby playing position.BMC genetics · 2017Article
Corrections and comments
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to quantify the ACE I/D and ACTN3 R577X (rs1815739) genetic variants in elite rugby athletes (rugby union and league) and compare genotype frequencies to controls and between playing positions. The rugby athlete cohort consisted of 507 Caucasian men, including 431 rugby union athletes that for some analyses were divided into backs and forwards and into specific positional groups: front five, back row, half backs, centers, and back three. Controls were 710 Caucasian men and women. Real-time PCR of genomic DNA was used to determine genotypes using TaqMan probes and groups were compared using χ(2) and odds ratio (OR) statistics. Correction of P values for multiple comparisons was according to Benjamini-Hochberg. There was no difference in ACE I/D genotype between groups. ACTN3 XX genotype tended to be underrepresented in rugby union backs (15.7%) compared with forwards (24.8%, P = 0.06). Interestingly, the 69 back three players (wings and full backs) in rugby union included only six XX genotype individuals (8.7%), with the R allele more common in the back three (68.8%) than controls (58.0%; χ(2) = 6.672, P = 0.04; OR = 1.60) and forwards (47.5%; χ(2) = 11.768, P = 0.01; OR = 2.00). Association of ACTN3 R577X with playing position in elite rugby union athletes suggests inherited fatigue resistance is more prevalent in forwards, while inherited sprint ability is more prevalent in backs, especially wings and full backs. These results also demonstrate the advantage of focusing genetic studies on a large cohort within a single sport, especially when intrasport positional differences exist, instead of combining several sports with varied demands and athlete characteristics.
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