Evidence map›Paper›PMID 26757368›Full record

Trial reportHuman brain mapping2016

Behavioural and neurofunctional impact of transcranial direct current stimulation on somatosensory learning.

Raphael Hirtz, Thomas Weiss, Ralph Huonker, Otto W Witte

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Transcranial direct-current stimulation modulates offline visual oscillatory activity: A magnetoencephalography study.Cortex; a journal devoted to the study of the nervous system and behavior · 2017
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Raphael HirtzHans Berger Department of Neurology, Jena University Hospital, Friedrich Schiller University, Jena, Germany.
Thomas WeissDepartment of Biological and Clinical Psychology, Friedrich Schiller University, Jena, Germany.
Ralph HuonkerBrain Imaging Center, Hans Berger Department of Neurology, Jena University Hospital, Friedrich Schiller University, Jena, Germany.
Otto W WitteHans Berger Department of Neurology, Jena University Hospital, Friedrich Schiller University, Jena, Germany.
Jena University Hospital · DEFriedrich Schiller University Jena · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the effect of repeated delivery of anodal transcranial direct current stimulation (tDCS) on somatosensory performance and long-term learning. Over the course of five days, tDCS was applied to the primary somatosensory cortex (S1) by means of neuronavigation employing magnetencephalography (MEG). Compared to its sham application, tDCS promoted tactile learning by reducing the two-point discrimination threshold assessed by the grating orientation task (GOT) primarily by affecting intersessional changes in performance. These results were accompanied by alterations in the neurofunctional organization of the brain, as revealed by functional magnetic resonance imaging conducted prior to the study, at the fifth day of tDCS delivery and four weeks after the last application of tDCS. A decrease in activation at the primary site of anodal tDCS delivery in the left S1 along retention of superior tactile acuity was observed at follow-up four weeks after the application of tDCS. Thus, we demonstrate long-term effects that repeated tDCS imposes on somatosensory functioning. This is the first study to provide insight into the mode of operation of tDCS on the brain's response to long-term perceptual learning, adding an important piece of evidence from the domain of non-invasive brain stimulation to show that functional changes detectable by fMRI in primary sensory cortices participate in perceptual learning.

Indexed as

AdolescentAdultDouble-Blind MethodFemaleFollow-Up StudiesHumansLearningMagnetic Resonance ImagingMagnetoencephalographyMalePhotic StimulationSomatosensory CortexTouchTranscranial Direct Current StimulationYoung Adultlongitudinal fMRIneuronavigationperceptual learning(repeated) transcranial direct current stimulationsomatosensory learning

Identifiers

PMID26757368
PMCPMC6867357
OpenAlexW2233905913

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.