Evidence map›Paper›PMID 26757363›Full record

SynthesisMedical science monitor : international medical journal of experimental and clinical research2016

The MTHFR C677T Polymorphism and Risk of Intracerebral Hemorrhage in a Chinese Han Population.

Xin Hu, Chuanyuan Tao, Zhiyi Xie, Yunke Li, Jun Zheng, Yuan Fang, Sen Lin, Hao Li, Chao You

Open access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Medical science monitor : international medical journal of experimental and clinical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 5 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Genetic susceptibility to cerebrovascular disease: A systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018
    Pooled it
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xin HuStroke Clinical Research Unit, Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland).
Chuanyuan TaoStroke Clinical Research Unit, Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland).
Zhiyi XieStroke Clinical Research Unit, Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland).
Yunke LiStroke Clinical Research Unit, Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland).
Jun ZhengStroke Clinical Research Unit, Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland).
Yuan FangStroke Clinical Research Unit, Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland).
Sen LinStroke Clinical Research Unit, Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland).
Hao LiStroke Clinical Research Unit, Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland).
Chao YouStroke Clinical Research Unit, Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland).
Sichuan University · CNWest China Hospital of Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMethylenetetrahydrofolate reductase (MTHFR) C677T polymorphism has been speculated to be and extensively investigated as a risk factor for various vascular diseases, including intracerebral hemorrhage (ICH). However, results from published studies regarding the role of C677T polymorphism in ICH risk in Chinese populations were contradictory rather than conclusive. MATERIAL/

methodsIn this study, a total of 180 ICH patients and 180 matched controls of Chinese Han ethnicity were enrolled. The MTHFR C677T polymorphism was genotyped by polymerase chain reaction-ligation detection reaction (PCR-LDR). A meta-analysis was conducted by combining our data with previous relevant studies in Chinese populations.

resultsIn our case-control study, similar allele frequency (p=0.492) and genotype distribution (p=0.748) of MTHFR C677T polymorphism were detected between ICH patients and controls. Further analysis based on hematoma location did not show a significant association. When combined with previous studies, however, C677T polymorphism was found to be significantly associated with an increased risk for ICH in Chinese populations (recessive model: OR=1.57, 95%CI=1.29-1.91). When focusing on the Han ethnicity, carriers of the TT genotype had an increased risk of ICH (recessive model: OR=1.36, 95%CI=1.05-1.75).

conclusionsIn this case-control study we did not observe that the MTHFR C677T polymorphism was associated with ICH risk in people of Chinese Han ethnicity. However, when combined with previous published studies, a significant association of C677T polymorphism with an increased risk of ICH was detected in Chinese populations, and also in the subgroup analysis focusing on Han ethnicity.

Indexed as

Polymorphism, Single NucleotideAdultAgedAsian PeopleCase-Control StudiesCerebral HemorrhageChinaFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansMaleMethylenetetrahydrofolate Reductase (NADPH2)Middle AgedOdds RatioMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, human

Identifiers

PMID26757363
PMCPMC4716714
OpenAlexW2237172764

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.