ArticleJournal of Alzheimer's disease : JAD2016
Cerebral Small Vessel Disease and Motoric Cognitive Risk Syndrome: Results from the Kerala-Einstein Study.
Article in Journal of Alzheimer's disease : JAD, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Association of motoric cognitive risk syndrome with depression in older adults: a meta-analysis and systematic review of cross-sectional and cohort studies.BMC geriatrics · 2024Pooled it
- Gait in cerebral small vessel disease, pre-dementia, and dementia: A systematic review.International journal of stroke : official journal of the International Stroke Society · 2023Pooled it
- Mechanisms of motoric cognitive risk-Hypotheses based on a systematic review and meta-analysis of longitudinal cohort studies of older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Pooled it
- Article
- Clinical and neuroimaging correlates of motoric cognitive risk syndrome in cerebral small vessel disease: a cross-sectional study.Frontiers in aging neuroscience · 2026Article
- Greater White Matter Hyperintensities and More Severe Cognitive Dysfunction in Mild Cognitive Impairment With Motoric Cognitive Risk Syndrome.Journal of Korean medical science · 2025Article
- Motoric Cognitive Risk Syndrome and Risk of Cardiovascular Disease: A Population-Based Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Clinical, biological, and neuroimaging profiles for motoric cognitive risk syndrome in older adults: The MIND-China study.Journal of internal medicine · 2025Article
- Electrocardiographic markers in Motoric Cognitive Risk syndrome.Gerontology · 2025Article
- Translation and Validation of the Malayalam Version of the Subjective Happiness Scale.Social indicators research · 2025Article
- Article
- Distinct Patterns of Brain Atrophy in Amnestic Mild Cognitive Impairment and Motoric Cognitive Risk Syndromes.Neuro-degenerative diseases · 2024Article
- White Matter Hyperintensities Are Associated with Slower Gait Speed in Older Adults without Dementia.Neuro-degenerative diseases · 2024Article
- Epidemiology of Motoric Cognitive Risk Syndrome in the Kerala Einstein Study: Protocol for a Prospective Cohort Study.JMIR research protocols · 2023Article
- Association between motoric cognitive risk syndrome and future falls among Chinese community-dwelling elderly: A nationwide cohort study.Brain and behavior · 2023Article
- Potential Imaging Biomarkers of Cognitive Frailty.Annals of geriatric medicine and research · 2023Article
- Prevalence and predictors of Motoric Cognitive Risk syndrome in a community-dwelling older Scottish population: A longitudinal observational study.International journal of geriatric psychiatry · 2022Observational
- Cognitive impairment and microvascular function in end-stage renal disease.International journal of methods in psychiatric research · 2022Article
- Motoric Cognitive Risk Syndrome: Prevalence and Cognitive Performance. A cross-sectional study.Lancet regional health. Americas · 2022Article
- The association of motoric cognitive risk with incident dementia and neuroimaging characteristics: The Atherosclerosis Risk in Communities Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe contribution of cerebral small vessel disease to cognitive decline, especially in non-Caucasian populations, is not well established.
objectiveWe examined the relationship between cerebral small vessel disease and motoric cognitive risk syndrome (MCR), a recently described pre-dementia syndrome, in Indian seniors.
methods139 participants (mean age 66.6 ± 5.4 y, 33.1% female) participating in the Kerala-Einstein study in Southern India were examined in a cross-sectional study. The presence of cerebral small vessel disease (lacunar infarcts and cerebral microbleeds (CMB)) and white matter hyperintensities on MRI was ascertained by raters blinded to clinical information. MCR was defined by the presence of cognitive complaints and slow gait in older adults without dementia or mobility disability.
resultsThirty-eight (27.3%) participants met MCR criteria. The overall prevalence of lacunar infarcts and CMB was 49.6% and 9.4% , respectively. Lacunar infarcts in the frontal lobe, but no other brain regions, were associated with MCR even after adjusting for vascular risk factors and presence of white matter hyperintensities (adjusted Odds Ratio (aOR): 4.67, 95% CI: 1.69-12.94). Frontal lacunar infarcts were associated with slow gait (aOR: 3.98, 95% CI: 1.46-10.79) and poor performance on memory test (β: -1.24, 95% CI: -2.42 to -0.05), but not with cognitive complaints or non-memory tests. No association of CMB was found with MCR, individual MCR criterion or cognitive tests.
conclusionsFrontal lacunar infarcts are associated with MCR in Indian seniors, perhaps, by contributing to slow gait and poor memory function.
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