ReviewDevelopmental dynamics : an official publication of the American Association of Anatomists2016
Force transmission in epithelial tissues.
Review in Developmental dynamics : an official publication of the American Association of Anatomists, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed.
- Using tunable hydrogel microparticles to measure cellular forces.Nature protocols · 2026Review
- Deep Invaginations of Nuclear Envelope Coordinate Spatial Organization of Chromatin in Epithelium.bioRxiv : the preprint server for biology · 2026Article
- Article
- Linking Planar Cell Polarity to Mechanotransduction During Morphogenesis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Shape, Strain, and Stability: Epithelia Under High Strain.bioRxiv : the preprint server for biology · 2025Article
- Viscous dissipation in the rupture of cell-cell contacts.Nature materials · 2025Article
- Rac1 promotes kidney collecting duct repair by mechanically coupling cell morphology to mitotic entry.Science advances · 2024Article
- The Effect of Substrate Stiffness on Elastic Force Transmission in the Epithelial Monolayers over Short Timescales.Cellular and molecular bioengineering · 2023Article
- Bioinks of Natural Biomaterials for Printing Tissues.Bioengineering (Basel, Switzerland) · 2023Article
- Article
- The developing murine kidney actively negotiates geometric packing conflicts to avoid defects.Developmental cell · 2023Article
- α-Catenin-dependent vinculin recruitment to adherens junctions is antagonistic to focal adhesions.Molecular biology of the cell · 2022Article
- Appropriate tension sensitivity of α-catenin ensures rounding morphogenesis of epithelial spheroids.Cell structure and function · 2022Article
- Three-Dimensional Bioprinting of Decellularized Extracellular Matrix-Based Bioinks for Tissue Engineering.Molecules (Basel, Switzerland) · 2022Review
- Actin-based force generation and cell adhesion in tissue morphogenesis.Current biology : CB · 2021Review
- Elasticity, Stability, and Quasioscillations of Cell-Cell Junctions in Solid Confluent Epithelia.Biophysical journal · 2020Article
- Src kinases relax adherens junctions between the neighbors of apoptotic cells to permit apical extrusion.Molecular biology of the cell · 2020Article
- Neuronal immunoglobulin superfamily cell adhesion molecules in epithelial morphogenesis: insights fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- The Role of Tricellulin in Epithelial Jamming and Unjamming via Segmentation of Tricellular Junctions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- The Physical Mechanisms ofGenetics · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In epithelial tissues, cells constantly generate and transmit forces between each other. Forces generated by the actomyosin cytoskeleton regulate tissue shape and structure and also provide signals that influence cells' decisions to divide, die, or differentiate. Forces are transmitted across epithelia because cells are mechanically linked through junctional complexes, and forces can propagate through the cell cytoplasm. Here, we review some of the molecular mechanisms responsible for force generation, with a specific focus on the actomyosin cortex and adherens junctions. We then discuss evidence for how these mechanisms promote cell shape changes and force transmission in tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.