ArticlePediatric research2016
Predictive factors and practice trends in red blood cell transfusions for very-low-birth-weight infants.
Article in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Stopping enteral feeds for prevention of transfusion-associated necrotising enterocolitis in preterm infants.The Cochrane database of systematic reviews · 2019Pooled it
- Long-term outcome of brain structure in female preterm infants: possible associations of liberal versus restrictive red blood cell transfusions.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2021Trial
- Red blood cell transfusion exacerbates phlebotomy-induced anemia-associated neuroinflammation in murine neonates.Transfusion · 2026Article
- Neonatal phlebotomy-induced anemia compromises mitochondrial bioenergetics in the developing hippocampus.bioRxiv : the preprint server for biology · 2025Article
- Adverse outcomes after red blood cell transfusion in very low birth weight infants in a resource-restricted hospital.Transfusion · 2025Article
- Risk factors associated with anemia of prematurity requiring red blood cell transfusion in very low birth weight infants: a retrospective study.BMC pediatrics · 2024Article
- Thresholds for blood transfusion in extremely preterm infants: A review of the latest evidence from two large clinical trials.Frontiers in pediatrics · 2022Review
- Iatrogenic Blood Loss in Very Low Birth Weight Infants and Transfusion of Packed Red Blood Cells in a Tertiary Care Neonatal Intensive Care Unit.Children (Basel, Switzerland) · 2021Article
- Are single-donor red blood cell transfusions still relevant for preterm infants?Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Optimizing Measurement of Vascular Endothelial Growth Factor in Small Blood Samples of Premature Infants.Scientific reports · 2019Article
- Epidemiology of Necrotizing Enterocolitis: New Considerations Regarding the Influence of Red Blood Cell Transfusions and Anemia.Clinics in perinatology · 2019Review
- Elevated brain oxygen extraction fraction in preterm newborns with anemia measured using noninvasive MRI.Journal of perinatology : official journal of the California Perinatal Association · 2018Observational
- Transfusion practice in neonates.Korean journal of pediatrics · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundRed blood cell (RBC) transfusions in very-low-birth-weight (VLBW) infants, while common, carry risk. Our objective was to determine clinical predictors of and trends in RBC transfusions among VLBW infants.
methodsRBC transfusion practice and its clinical predictors in 1,750 VLBW (≤1,500 g) infants were analyzed in a single-center cohort across sequential epochs: 2000-2004 (Epoch 1), 2005-2009 (Epoch 2), and 2010-2013 (Epoch 3).
resultsOverall, 1,168 (67%) infants received ≥1 transfusions. The adjusted likelihood of ≥1 transfusions decreased for each 1-g/dl increment in initial hemoglobin concentration following birth, for females, and for each 100-g increment in birth weight. The adjusted likelihood of ≥1 transfusions increased with infants receiving mechanical ventilation, with increasing length of hospital stay, necrotizing enterocolitis, and nonlethal congenital anomalies requiring surgery. The adjusted mean (SEM) number of transfusions per patient was decreased in Epoch 3, compared with Epoch 1 and Epoch 2. For an initial hemoglobin of ≥16.5 g/dl, the predicted probability of being transfused was ≤50%.
conclusionAdjusted RBC transfusions declined and female sex conferred an unexplained protection over the study period. Modest increases in initial hemoglobin by placentofetal transfusion at delivery may reduce the need for RBC transfusion.
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