ArticleStem cells (Dayton, Ohio)2016
Hair Follicle Bulge Stem Cells Appear Dispensable for the Acute Phase of Wound Re-epithelialization.
Article in Stem cells (Dayton, Ohio), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 52 citations in OpenAlex.
- Hair Follicle Stem Cells: Emerging Physiology and Therapeutic Applications.Stem cell reviews and reports · 2026Review
- Hair follicle transplantation promotes skin ulcer healing in a mouse model of experimental diabetes.Scientific reports · 2025Article
- The Utility of De-epithelialization in Subcutaneous Skin Flap Transposition.Plastic and reconstructive surgery. Global open · 2025Article
- Wnt10b Regulation of Hair Follicle Development, Regeneration, and Skin Diseases.Stem cell reviews and reports · 2025Review
- Autografted hair follicles with dermal papilla removed promote wound repair and regeneration in Bama mini-pigs.Journal of molecular histology · 2025Article
- Autophagy in adult stem cell homeostasis, aging, and disease therapy.Cell regeneration (London, England) · 2025Review
- Extracellular Caspase-1 induces hair stem cell migration in wounded and inflamed skin conditions.The Journal of cell biology · 2024Article
- Article
- Melanocyte stem cells in the skin: Origin, biological characteristics, homeostatic maintenance and therapeutic potential.Clinical and translational medicine · 2024Review
- Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization.Cell stem cell · 2021Article
- Article
- TRPV1: Role in Skin and Skin Diseases and Potential Target for Improving Wound Healing.International journal of molecular sciences · 2021Review
- A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia?Biomedicines · 2021Article
- Diverse cellular players orchestrate regeneration after wounding.Experimental dermatology · 2021Article
- Wound healing: cellular mechanisms and pathological outcomes.Open biology · 2020Review
- IGF1- and BM-MSC-incorporating collagen-chitosan scaffolds promote wound healing and hair follicle regeneration.American journal of translational research · 2020Article
- Induction of hair follicle neogenesis with cultured mouse dermal papilla cells in de novo regenerated skin tissues.Journal of tissue engineering and regenerative medicine · 2019Article
- Olfactory receptor OR2AT4 regulates human hair growth.Nature communications · 2018Article
- Human nail stem cells are retained but hypofunctional during aging.Journal of molecular histology · 2018Article
- ROCK inhibitor Y-27632 maintains the propagation and characteristics of hair follicle stem cells.American journal of translational research · 2018Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
The cutaneous healing response has evolved to occur rapidly, in order to minimize infection and to re-establish epithelial homeostasis. Rapid healing is achieved through complex coordination of multiple cell types, which importantly includes specific cell populations within the hair follicle (HF). Under physiological conditions, the epithelial compartments of HF and interfollicular epidermis remain discrete, with K15(+ve) bulge stem cells contributing progeny for HF reconstruction during the hair cycle and as a basis for hair shaft production during anagen. Only upon wounding do HF cells migrate from the follicle to contribute to the neo-epidermis. However, the identity of the first-responding cells, and in particular whether this process involves a direct contribution of K15(+ve) bulge cells to the early stage of epidermal wound repair remains unclear. Here we demonstrate that epidermal injury in murine skin does not induce bulge activation during early epidermal wound repair. Specifically, bulge cells of uninjured HFs neither proliferate nor appear to migrate out of the bulge niche upon epidermal wounding. In support of these observations, Diphtheria toxin-mediated partial ablation of K15(+ve) bulge cells fails to delay wound healing. Our data suggest that bulge cells only respond to epidermal wounding during later stages of repair. We discuss that this response may have evolved as a protective safeguarding mechanism against bulge stem cell exhaust and tumorigenesis. Stem Cells 2016;34:1377-1385.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.